Shuk-mei, Ho Shuk-mei Ho
Jacob G. Schmidlapp Professor and Chair
130 Kettering
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Research Description:

Shuk-mei Ho, PhD is internationally recognized for her expertise in the role of hormones and endocrine disruptors on disease development including tumorigenesis in the prostate, ovary, endometrium and breast. She has also made significant contributions to the impact of heavy metals, oxidative stress and inflammation to carcinogenesis; discovery of biomarkers for cancer detection and patient classification, and mechanism-based drug development. Her research is pivotally anchored on modern investigative tools for genomics, transcriptomics, proteomics, epigenomics, and informatics research that focus on improving predictive, preventive medicine.

Dr. Ho’s current research extends to developmental bases of disease susceptibility by applying epigenetics to epidemiological studies, addressing two of the important challenges of research in environmental exposure and human health - multiple exposures at various developmental stages and the trans-generational effects of exposure. Her recent findings on EDC exposure, including Bisphenol A, raise concerns on in utero exposure to EDC in food and drinking water. She also has preliminary data implicating epigenetic dysregulation of transcriptional regulation as the bases of polycyclic aromatic hydrocarbons (PAHs)-associated disorders such as asthma and cancer.

Past president of the Society for Basic Urological Research, Dr. Ho is an active participant in the American Urologic Society, the Endocrine Society, the Society for Basic Urologic Research, Prostate Cancer Research Program, the Society of Toxicology, and the American Association for Cancer Research. She regularly chairs scientific review and policy committees for the National Institutes of Health and the Department of Defense. She is a member of the Integration Panel of the Department of Defense Congressionally Directed Prostate Cancer Research Program, and is on the Emerging Science Committee of the National Academy of Science. Dr. Ho was honored in 2007 by the Senate of the 127th General Assembly of Ohio, and has received the Women in Urology Award from the SBUR and the Society of Women in Urology, primarily on her discovery of the adverse effects of early exposure to bisphenol A on prostate cancer risk. Dr. Ho also participated in a national review of key scientific literature linking environmental factors to female reproductive disorders. Collectively, her work has contributed to the recently passed “Toxic Toy Bill” in California and the re-examination of the risk of bisphenol A by the National Toxicology Program.

Dr. Ho has published over 178 papers in prestigious, peer-reviewed journals. She also serves as the Director of the NIEHS funded Center for Environmental Genetics, and the Director of the Genomic Microarray Laboratory.

Related News:
4/1/2014 New study links BPA and prostate cancer in humans
3/4/2014 Study links chemical exposure to prostate cancer
3/3/2014 BPA Linked to Prostate Cancer, Study Shows
2/1/2014 Community engagement drives new pilot study on fracking and air quality
1/2/2014 2013 TOP RESEARCH AWARD
11/5/2013 Breast Cancer Research
10/24/2013 Cancer rates climbing in Butler County
9/4/2013 Environmental Health Faculty, Students Enjoy Successful Conference in Basel Switzerland
8/29/2013 Researchers Identify Key Protein's Role in Cancer Development
7/1/2013 NIEHS spurs investigation into the health effects of e-waste recycling
6/21/2013 Center for Environmental Genetics Announces Career Development Awards
6/17/2013 $8.7 Million Grant Supports 'Gene-Environment Interaction' Research
2/1/2013 Dr. Ho's group uses saliva for study on methylation in asthma
3/28/2012 Chinese Professors Visit UC to Share Knowledge on E-Waste
12/14/2011 Master's of Public Health Program Moves to Environmental Health
8/8/2011 Cancer Biomarker—Detectable by Blood Test—Could Improve Prostate Cancer Detection
1/4/2011 Epigenetics and Disease Outcome
1/11/2010 UC wins $5M stimulus grant for lab renovations
9/18/2009 Estrogen May Explain the Higher PCa Risk in Blacks
4/1/2009 Study Links Maternal Exhaust Exposure to Childhood Asthma
2/15/2009 Prenatal Exposure to Traffic Pollution May Lead to Asthma
2/15/2009 Pollution Link to Asthma in Womb
2/1/2009 Study Offers Insight into Endocrine Disruption by Soy
1/21/2009 Shuk-mei Ho interview with Channel 12 News: Colon Cancer Treatment
1/16/2009 Cancer ‘Hot Spots’ Found
1/16/2009 Genetic Data May Predict Colon Cancer Odds
1/16/2009 Shuk-mei Ho Interview with WNKU discussing Colon Cancer Markers
1/16/2009 Genetic Data May Predict Colon Cancer Odds
11/23/2008 Environmental Health Chair Leads Organizing Committee for Meeting
5/19/2008 UC Med School Hauls in Funding
5/19/2008 Another Bastion of Research
4/1/2008 7.8 Million Grant Supports Gene-Environment Interaction Research
3/26/2008 UC Researcher Dr Shuk-mei Ho Wins $2.6M to Study Prostate Cancer Link Ho
2/26/2008 Distinguished Lecture Series on Advances in Toxicology and Risk Assessment
12/1/2007 Environment Health Chair Selected to Assist With Study
7/22/2007 UC Environmental Health Chair Recognized Nationally for Urologic Research Excellence
3/12/2007 Plastic Dangers
7/1/2006 Chemical in Plastics is Tied to Prostate Cancer
1/1/2006 Series on Experimental Oncology and its Clinical Application

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