Human Genome Research              

The objectives of this research include:
1. Identification within a species of genetic polymorphisms associated with differences in response to environmental agents;
2. Elucidation of the molecular genetic basis of these polymorphisms;
3. Determination of the prevalence of different alleles in human populations and the mode of inheritance through family studies;
4. Evaluation of the impact of a given polymorphism on human health; and

Clinical pharmacogenetics and pharmacogenomics. This research increasingly has focused on the importance of "multiplex phenotypes" (i.e. role of two or more genes involved in environmental toxicity or cancer), as well as the closer integration with genomics and the Human Genome Project.

Faculty performing research in this field:
Dan Nebert



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