Molecular Toxicology              

The long-range goals of our molecular toxicology research are to investigate the mechanisms by which genotoxic and non-genotoxic environmental agents are metabolized to toxic intermediates. The aim is to determine how the genotoxic agents interact with DNA and alter the chemical structure of DNA, how DNA damage leads to mutations, and how cellular mutation avoidance mechanisms (e.g., DNA repair and cell cycle arrest) function to counteract mutagenesis, and focusing on the role that individual differences in genetic makeup play in determining the outcomes of exposure.

We seek to:
  1 understand how differences in metabolism influence the potency and target organ specificity of genotoxic agents;
  2 develop sensitive biomarkers for exposure endpoints to use as a basis for determining individual responses to exposure;
  3 understand molecular mechanisms of each response;
  4 determine how signal transduction in DNA repair induced by toxic agents affects outcome
  5 understand how specific gene polymorphisms affect genetic stability

Faculty performing research in this field:
Howard Shertzer, Michael Borchers, Daniel Nebert, Marian Miller,
Mary Beth Genter, Jagjit Yadav

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