Respiratory Genomics              

Our research objectives are to investigate the genetic determinants controlling the response of the lung to environmental agents. These objectives are to be met by the following specific aims:
1. To examine the genetic determinants of complex respiratory diseases including asthma, acute lung injury (neonatal alveolar proteinosis and adult respiratory distress syndrome), and lung cancer
2. To develop model systems of altered susceptibility to environmental injury (e.g., gene targeted, cell-directed, and conditional transgenesis in the mouse lung).
3. To examine developmental genomic programs that are evoked during epithelial injury and repair (e.g., lung genes under control of the mitogen- and stress-activated pathways).

Faculty performing research in this field:
Michael Borchers

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