Glenn Talaska

Professor, Associate Director Department of Environmental Health, Director, Division of Industrial and Environmental Hygiene and Biological Monitoring Component Program

Division: Industrial Hygiene

E-Mail: TALASKGG@UCMAIL.UC.EDU
Phone: 513-558-0519
Location: 143 Kettering Lab
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Glenn Talaska  is professor of Environmental Health at the University of Cincinnati College of Medicine.  He has a MSPH (Industrial Hygiene) from the University of Washington.  He earned his Ph.D. at the University of Texas Medical Branch.  Talaska was Research Toxicologist at the National Center for Toxicological Research.  Talaska’s research is on the development and validation of biomarkers of carcinogen exposure and effect.   Through the years this program has identified the major and disease- inducing carcinogen DNA adducts for bladder carcinogens 4-aminobiphenyl (tobacco smoke)  and benzidine (dye workers).    In addition he showed that the mechanism of action of benzidine DNA adducts was through the chromosomal aberrations they produced, while 4-aminobiphenyl caused specific mutations in cellular oncogenes.  The lab developed a method of carcinogen DNA adduct analysis that utilizes urothelial cells exfoliated into the urine as a source of target tissue DNA for bladder carcinogens; this allows easy non-invasive sampling of an internal target tissue.  This technique has allowed Talaska to study groups with occupational and environmental exposure to carcinogens.  For example, he has shown that adduct levels in exfoliated urothelial cells of non-smoking wives of smokers are 1.8 times higher than in the wives of non-smokers; and that the adduct levels in benzidine workers are 25 times higher than controls.  Glenn has published over 120 papers in journals such as Nature, PNAS, Cancer Research, JNCI,  Carcinogenesis as well as in the more specialized Industrial Hygiene journals.  He is on the editorial board of 5 Occupational and Public Health journals and has served as President of the Journal of Occupational and Environmental Health.  Talaska has successfully mentored 7 Ph. D. and 27 MS students to their degrees and is currently the mentor to 2 more MS students.   Talaska is the Vice-Chair of the ACGIH Biological Exposure Indices (BEI)  committee.  He is also Secretary of the Scientific Committee on Toxicology (SCOT) for the International Congress on Occupational Health.  Talaska has recently been appointed to the World Trade Center Health Program’s Scientific/Technical Advisory Committee.  He has been on the Scientific Advisory or Organizing Committees for over 15 international scientific meetings including every (triannual) International Society for Biological Monitoring  meeting since 1993.  Since 2001 Talaska has been the Chair of the University’s Radiation Safety Committee.   Talaska is the Associate Director of the Department of Environmental Health, the Director of the Environmental and Occupational Hygiene Division and Director of the Biomonitoring Component Program.  His current research is to determine the relationship between biomarkers of internal dose and reversible health effects in persons working with polycyclic aromatic hydrocarbons.  Groups studied include Firefighters, Coke Oven Workers and Tunnelers with the purpose to establish biological based exposure guidelines that will prevent disease in the millions of persons exposed to polycyclic aromatic compounds.

Related News:

  • 10/07/2013: Talaska Named Associate Chair of Environmental Health
  • 05/21/2007: Move It: Bike to Work
  • 03/09/2007: Bicycle Commuting Racks Up Big Miles for Pair of UC Faculty

  • Education

    University of Washington, Seattle, WA BS 1980 Molecular Biology

    University of Washington, Seattle, WA MSPH 1982 Envir. Helath (Ind. Hygiene)

    University of Texas Medical Branch, Galveston, TX PhD 1986 Genetic Toxicology

    Awards

    National Institute for Occupational Safety and Health Fellow, July 1991

    Dean’s Award for Academic Excellence, The University of Texas Medical Branch, 1987

    The Edward S. Reynolds Memorial Award for Research in Toxicology from the University of Texas Medical Branch, 1986.

    Professional Experience

    1981-1982: Industrial Hygienist, The United States Army Corps of Engineers

    1982-1986: Research Associate, Division of Genetic Toxicology Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, Texas

    1986-1989: Research Geneticist, National Center for Toxicological Research, Jefferson, Arkansas

    1989- Present: Assistant Professor, then Associate Professor, then Professor, Department of Environmental Health, University of Cincinnati, Cincinnati, OH

    Selected Publications

    Hopf, N., Carreón, T. and Talaska, G. (2009) Biological markers of carcinogenic exposure in the aluminum smelter industry, a systematic review. . J. Occup. Environ. Health, In Press.

    Hopf, N., Kirkeleit, J., Kramer, S., Succop, P., M.B., G., Carreon-Valencia, T., Mack, J. and Talaska, G. (2009) Urinary 1-hydroxypyrene levels in offshore workers. Int. Arch. Occup. Environ. Health, In Press.

    Talaska, G., Schumann, B., Vermeulen, R. and Peters, S. (2008) L’ ibe 1-hydroxypyrene de l’ACGIH offre-t-il une protection adequate? Bull. de’ informacion en sante’ environmentale, 19, 35-38.

    Peters, S., Talaska, G., Jönsson, B.A.G., Kromhout, H. and Vermeulen, R. (2008) Polycyclic Aromatic Hydrocarbon Exposure, Urinary Mutagenicity and DNA Adducts in Rubber Manufacturing Workers. Cancer Epidemiol. Biomark Prev., 17, 1452-59.

    Shertzer, H.G., Genter, M.B., Talaska, G., Curran, C.P., Nebert, D.W. and Dalton, T.P. (2007) 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes. Carcinogenesis, 28, 1371-78.

    Schnekenburger, M., Talaska, G. and Puga, A. (2007) Chromium cross-links HDAC1·DNMT1 complexes to chromatin inhibiting histone remodeling marks critical for transcriptional activation. Genes and Development, In Press.

    Guarrera, S., Sacerdote, C., Fiorini, L., Marsala, R., Polidoro, S., Gamberini, S., Saletta, F., Malaveille, C., Talaska, G., Vineis, P. and Matullo, G. (2007) Expression of DNA repair and metabolic genes in response to a flavonoid-rich diet. The British Journal of Nutrition, 98, 525-33.

    Castaño-Vinyals, G., Talaska, G., Alguacil, J., Dosemeci, M., Cantor, K.P., Malats, N., Real, F.X., Silverman, D., Serra, C., Carrato, A., Tardon, A., Garcia-Closas, R., Rothman, N., Kogevinas, M. and Vermeulen, R. (2007) Bulky DNA adducts and bladder cancer risk in non-smokers. Cancer Epidemiol. Biomark Prev., 16, 2155-59.

    Talaska, G., Ginsburg, D., LaDow, K., Puga, A., Dalton, T. and Warshawsky, D. (2006) Impact of Cyp1a2 or Ahr Gene Knockout in Mice: Implications for Biomonitoring Studies. Toxicol Letts., 162, 246-49.

    Talaska, G., Al-Zoughool, M., Malaveille, C., Fiorini, L., Schumann, B., Vietas, J., Peluso, M., Munnia, A., Bianchini, M., Allegro, G., Matullo, G., Sacerdote, C. and Vineis, P. (2006) Randomized controlled trial: effects of diet on DNA damage in heavy smokers. Mutagenesis, 21, 179-83.

    Ruder, A.M., Waters, M.A., Butler, M.A., Carreón, T., Calvert, G.M., Davis-King, K.E., Schulte, P.A., Sanderson, W.T., Ward, E.M., Connally, L.B., Heineman, E.F., Mandel, J.S., Morton, R.F., Reding, D.J., Rosenman, K.D., Talaska, G. and Group, B.C.C.S. (2006) Gliomas and farm pesticide exposure in men. Arch Environ Health 59, 650-657.

    Fischer, J.M., Robbins, S.B., Kannamkumarath, S.S., Al-Zoughool, M., Talaska, G., Stambrook, P. and Stringer, J.R. (2006) Exposure of mice to arsenic and/or benzo[a]pyrene does not increase the frequency of Aprt-deficient cells recovered from explanted skin of Aprt heterozygous mice. Environmental and molecular mutagenesis 47, 334-44. .

    Al-Zoughool, M. and Talaska, G. (2006) 4-aminobiphenyl N-glucuronidation by liver microsomes: optimization of the reaction conditions and characterization of the UDP-glucuronosyltransferase isoforms. J. Appld. Toxicol, 26, 524-532.

    Al-Zoughool, M., Succop, P., Desai, P., Vietas, J. and Talaska, G. (2006) Effect of N-glucuronidation on urinary bladder genotoxicity of 4-aminobiphenyl in male and female mice. Env. Toxicol. Pharmacol, 22, 153-159.

    Fischer, J.M., Robbins, S.B., Al-Zoughool, M., Kannamkumarath, S.S., Stringer, S.L., Larson, J.A., Caruso, J.A., Talaska, G., Stambrook, P.J. and Stringer, J.R. (2005) Co-mutagenic activity of arsenic and benzo[a]pyrene in mouse skin. Mut. Res., 588, 35-46.

    Carreón, T., Butler, M.A., Ruder, A.M., Waters, M.A., Davis-King, K.E., Calvert, G.M., Schulte, P.A., Sanderson, W.T., Ward, E.M., Connally, L.B., Heineman, E.F., Mandel, J.S., Morton, R.F., Reding, D.J., Rosenman, K.D. and Talaska, G. (2005) Gliomas and farm pesticide exposure in women. Environ Health Perspect., 13, 546-551.

    Al-Zoughool, M. and Talaska, G. (2005) High performance liquid chromatography method for determination of N-glucuronidation of 4-aminobiphenyl by mouse, rat and human liver microsomes. Anal. Biochem., 340, 352-58.

    Sonntag, D.M., de Boer, J., Medvedovic, M., Baxter, C.S., LeMasters, G., Dourson, M. and Talaska, G. (2004) Mutational biases associated with potential iron binding DNA motifs in rodent lac I and human p53 mutational databases. Mut. Res., 550, 73-88.

    Schumann, B.L., LaDow, K., Luse, N., Warshawsky, D., Pickens, W., Hoath, S., Kasting, G. and Talaska, G. (2004) Preliminary findings that kerosene alters the distribution of topically applied benzo(a)pyrene in mice. Polycyclic Aromatic Compounds, 24, 597-605.

    Henn, S.A., Anderson, K., Hecht, S.S., Gross, M., Succop, P. and Talaska, G. (2004) Carcinogen-DNA adducts are increased in the exfoliated urothelial cells of wives of smokers: biological monitoring of passive smoke exposure. Polycyclic Aromatic Compounds, 24, 475-485.

    DeBord, D.G., Savage, R.E.J., Drexler, H., Freeman, C., Groopman, J., Jayjock, M., McDiarmid, M., Morgan, M.S., Santella, R., Schulte, P., Talaska, G., Tardiff, R. and Viau, C. (2004) A Summary of the Workshop “Applying Biomarkers to Occupational Health Practice”. J. Occup. Environ. Hyg., 1, 57-60.

    Evans, C.D., LaDow, C., Schumann, B.L., Savage, R.E.J., Caruso, J., Vonderheide, A., Succop, P. and Talaska, G. (2004) Effect of Arsenic on Benzo[a]pyrene DNA Adduct Levels in Mouse Skin and Lung. Carcinogenesis, In Press.

    Sweet, N.D., Burroughs, G.E., Ewers, L. and Talaska, G. (2004) A field method for near-real-time analysis of perchloroethylene in end-exhaled air. Am. Ind. Hyg. Assoc. J., In Press.

    Shertzer, H.G., Dalton, T.P., Talaska, G. and Nebert, D.W. (2003) Decrease in 4-aminobiphenyl-Induced Methemoglobinemia in Cyp1a2(-/-) Knockout Mice. Toxicol. Appld. Pharmacol., 188, 200-201.

    Talaska, G. (2003) Aromatic amines and human urinary bladder cancer: exposure sources and epidemiology. Environmental Carcinogenesis and Ecotoxicology Reviews, 21, 29-44.

    Talaska, G. and Al-Zoughool, M. (2003) Aromatic amines and biomarkers of human exposure. J. Environ. Sci. Health Environ. Carcino. Ecotoxicol. Revs., In Press.

    Tsuneoka, Y., Dalton, T.P., Miller, M.M., Clay, C.D., Shertzer, H.G., Talaska, G., Medvedovic, M. and Nebert, D.W. (2003) 4-Aminobiphenyl-Induced Liver and Urinary Bladder DNA Adduct Formation in Cyp1a2(-/-) and Cyp1a2(+/+) Mice. J. Natl. Cancer Inst., 95, 1227-1237.

    Maier, A., Schumann, B.L., Chang, X.Q., Talaska, G. and Puga, A. (2002) Arsenic co-exposure potentiates benzo a pyrene genotoxicity. Mutat. Res. Genet. Toxicol. Environ. Mutagen., 517, 101-111.

    Schneider, J., Warshawsky, D., Mitchell, K., Talaska, G., Ladow, K., Gear, R., Lu, F., Yan, M. and Heffelfinger, S. (2002) Effects of DMBA preparation on DMBA-induced rat mammary carcinogenesis. Polycyclic Aromatic Compounds, 22, 831-839.

    Shertzer, H.G., Dalton, T.P., Talaska, G. and Nebert, D.W. (2002) Decrease in 4-aminobiphenyl-induced methemoglobinemia in Cyp1a2(-I-) knockout mice. Toxicology and applied pharmacology, 181, 32-37.

    Siner, A., Xue, W.L., Talaska, G., Warshawsky, D., Gray, D.L., Nines, R., Wang, Y., Yao, R.S. and Stoner, G.D. (2002) The effect of 7H-dibenzo c,g carbazole and benzo a pyrene mixture on DNA adduct formation in strain A/J mouse model: Preliminary report. Polycyclic Aromatic Compounds, 22, 893-897.

    Talaska, G., Maier, A., Henn, S., Booth-Jones, A., Tsuneoka, Y., Vermeulen, R. and Schumann, B.L. (2002) Carcinogen biomonitoring in human exposures and laboratory research: validation and application to human occupational exposures. Toxicology Letters, 134, 39-49.

    Vermeulen, R., Talaska, G., Schumann, B., Bos, R.P., Rothman, N. and Kromhout, H. (2002) Urothelial cell DNA adducts in rubber workers. Environmental and Molecular Mutagenesis, 39, 306-313.

    Warshawsky, D., Dowty, H.V., LaDow, K., Succop, P. and Talaska, G. (2002) Reduction of a 7,12-dimethylbenz a anthracene DNA adduct in rat mammary tissue in vivo when pretreated with tamoxifen. Toxicology Letters, 132, 71-79.

    Xue, W.L., Siner, A., Rance, M., Jayasimhulu, K., Talaska, G. and Warshawsky, D. (2002) A metabolic activation mechanism of 7H-dibenzo c,g carbazole via O-quinone. Part 2: Covalent adducts of 7H- dibenzo c,g carbazole-3,4-dione with nucleic acid bases and nucleosides. Chemical Research in Toxicology, 15, 915-921.

    Uno, S., Dalton, T.P., Shertzer, H.G., Genter, M.B., Warshawsky, D., Talaska, G. and Nebert, D.W. (2001) Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels,. Biochem. Biophys. Res. Commun., 289, 1049-1056.

    Xue, W., Schneider, J., Mitchell, K., Jaeger, M., Nanayakkara, V., Talaska, G. and Warshawsky, D. (2001) Trans-3,4-Dihydrodiol-anti-1,2-epoxy-1,2,3,4-tetrahydrodibenz[a,j]acridine involvement in dibenz[a,j]acridine DNA adduct formation in mouse skin. Chem. Res. Toxicol., 14, 871-878.

    Lee, J-H., Roh, J.H., Burks, D., Warshawsky, D. and Talaska, G. (2000) Skin Cleaning with Kerosene Facilitates Passage of Carcinogens to the Lungs of Animals Treated with Used Gasoline Engine Oil, Appld. Occup. Environ. Hyg., 15, 362-369.

    Miller ML, Vasunia K, Talaska G, Andringa A, de Boer J, Dixon K. (2000) The tumor promoter, TPA, enhances benzo(a)pyrene and benzo(a)pyrene diolepoxide mutagenesis in Big Blue mouse skin. Environ Mol Mutagen 35, 319-327,

    Dowty, H.V., Xue, W., LaDow, K., Talaska, G. and Warshawsky, D. (2000). One-electron oxidation is not a major route of metabolic activation and DNA binding for the carcinogen 7H-dibenzo[c,g]carbazole in vitro and in mouse liver and lung. Carcinogenesis 21, 991-998.

    O’Brien, T., Babcock, G., Cornelius, J.,Dingeldein, M., Talaska, G., Warshawsky, D., and Mitchell, K. (2000). A comparison of apoptosis and necrosis induced by hepatotoxins in HepG2 cells. Toxicol. Appld. Pharmacol. 164, 280-290.

    Lee, J-H., Roh, J.H., Burks, D., Warshawsky, D. and Talaska, G. (2000) Study on measurement of carcinogen-DNA adducts in exfoliated urothelial cells in workers by 32P-postlabelling methods. Kor. Ind. Hyg. Assoc. J., 10, 1-17.

    Warshawsky, D., Dowty, H., Xue, W., Mitchell, K., Schneider, J., LaDow, K., and Talaska, G. (2000). Comparison of N-heterocyclic aromatics dibenzo[c,g]carbazole and dibenz[a,j]acridine: metabolism, DNA binding and mutations. Polycyclic Aromatic Compounds, in press.

    Dowty, H.V., LaDow, K., Talaska, G. and Warshawsky, D. (2000) Reduction in 7,12-dimethylben[a]anthracene DNA adducts due to tamoxifen pretreatment in rat mammary tissue, Carcinogenesis, 21, 991-998.

    Roh, J-H., Park, Y-J., Kim, C.N., Lim, NG, Lee, SH, Song, JS, Won, JU, Talaska, G, (2000) Effect of temperature on the Breakthrough of a Charcoal Tube during Vinyl Chloride Monomer Sampling, Am. Ind. Hyg. Assoc. J. In Press.

    Drexelius, R.J., Carwardine, K., Jaeger, M and Talaska, G. (1999) Barrier cream application reduces the formation of DNA adducts in lung tissue of mice dermally exposed to used gasoline engine oil, Appl. Occup. Environ. Hyg., 14, 838-844.

    Lee JH, Talaska G. Effects of kerosene cleaning on the formation of DNA adducts in the skin and lung tissues of mice dermally exposed to used gasoline engine oil. J Toxicol Environ Health 56, 46370, 1999

    Warshawsky, D., Mitchell, K., Xue, W., Jaeger, M. and Talaska, G. (1999) Comparative oncogenic activation of 7H-dibenzo(c,g) carbazole and dibenz(a,j) acridine, Polycyclic Aromatic Compounds, 16, 173-179.

    Bhatnagar, V.K. and Talaska, G. (1999) Carcinogen Exposure and Effect Biomarkers (Invited Review) Toxicol. Lett., 108, 107-116.

    Malaveille, C., Hautefeuille, A., Pignatelli, B., Talaska, G., Vineis, P. and Bartsch, H. (1998) Antimutagenic dietary phenolics as antigenotoxic substances in urothelium of smokers, Mutat. Res., 402, 219-224.

    Calvert, G., Talaska, G., Mueller, C., Fajen, J., Fleming, L. and Briggle, T. (1998) Evaluation of biological markers among US fumigation workers exposed to methyl bromide. Mutat. Res. , 417, 115-128.

    Underwood, P.M., Zhou, Q., Jaeger, M., Reilman, R., Pinney, S., Warshawsky. D. and Talaska, G. (1997) Chronic, topical administration of 4-aminobiphenyl induces tissue-specific DNA adducts in mice, Toxicol. Appl. Pharmacol., 144, 125-131.

    Rothman, N., Zenser, T., Talaska, G. (1997) Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers, Cancer Epidemiol. Biomark Prev., 6, 1039-1042.

    O’Connor, P., Fremont, S., Schneider, J., Dowty, H., Jaeger, M. Talaska, G. and Warshawsky, D. (1997) Combination of high performance liquid chromatography and thin layer chromatography separation of 5 adducted nucleotides isolated from liver, resulting from intra peritoneal administration with 7H-dibenzo[c,g]carbazole to mice, J. Chromatog., 700, 49-57.

    Culp, S.J., Roberts, D.W., Talaska, G., Lang, N.P., Fu, P.P., Lay, J.O., Teitel, C.H., Snawder, J.E., Von Tungeln, L.S. and Kadlubar, F.F. (1997) Immunochemical 32P-postlabelling and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation and peroxidation, Mutat. Res., 378, 97-112.

    Sanderson, T., Talaska, G., Zaebst, D., Davis-King, K. and Calvert, G. (1997) Pesticide Prioritization for a brain cancer case-control study, Environ. Res., 74, 133-144.

    Puhala, E., Lemasters, G., Smith, L., Talaska, G., Simpson, S., Joyce, J., Trinh, K. and Lu, J. (1997) Jet fuel exposure in the United States Air Force, Appl. Occup. Environ. Hyg., 12, 606-610.

    DeMarini, D.M., Brooks, L., Bhatnagar, V.K., Hayes, R.B., Eischen, B.T., Shelton, M.L., Zenser, T.V., Talaska, G., Kashyap, S.K., Dosemeci, M., Kashyap, R., Parikh, D.J., Lakshmi, V., Hsu, F., Davis, B.B., Jaeger, M., and Rothman, N. (1997) Urinary mutagenicity as a biomarker in benzidine-exposed workers: Correlation with urinary metabolites and urothelial DNA adducts, Carcinogenesis, 18, 981-988.

    Zhou, Q., Talaska, G., Jaeger, M., Bhatnagar, V.K., Hayes, R.B., Zenser, T.V., Kashyap, S.K., Lakshmi, V.M., Kashyap, R., Dosemeci, M., Hsu, F.F., Parikh D.J., Davis, B.B., and Rothman, N. (1997) Benzidine-DNA adducts levels in human peripheral white blood cells correlate significantly with levels in exfoliated urothelial cells, Mutat. Res.,393, 199-205.

    Cheu, J., Talaska, G., Miller, M., Rice, C. and Warshawsky, D. (1997) Benzo[a]pyrene coated ferric oxide and aluminum oxide particles: uptake, metabolism and DNA binding in hamster pulmonary alveolar macrophages and tracheal epithelial cells in vitro, Carcinogenesis, 18, 167-175.

    Levine, J., Talaska, G., Boeniger, M.F., Suruda, A., Waters, M.A. and Schulte, P.A. (1997) Utility of epithelial cell micronuclei in the assessment of intermittent exposures. Biomarkers, 2, 135-138.

    Talaska, G., Jaeger, M., Reilman, R., Collins, T. and Warshawsky, D. (1996) Chronic, topical exposure to benzo[a]pyrene induces relatively high steady state levels of DNA adducts in target tissues and alters kinetics of adduct loss, Proc. Natl. Acad. Sci. (USA), 93, 7789-7793.

    Rothman, N., Bhatnagar, V.K., Hayes, R.B., Kashyap, R., Parikh, D.J., Kashyap, S.K., Schulte, P.A., Butler, M.A., Jaeger, M. and Talaska, G. (1996) The impact of interindividual variability in N-acetyltransferase activity on benzidine urinary metabolites and urothelial DNA adducts in exposed workers, Proc. Natl. Acad. Sci. (USA), 93, 5084-89.

    Malaveille, C., Hautefeuille, A., Pignatelli, B., Talaska, G., Vineis, P. and Bartsch, H. (1996) Dietary phenolics as antimutagens and inhibitors of tobacco-related DNA adduction in the urothelium of smokers. Carcinogenesis, 17, 2193-2200.

    Talaska, G. Zhou, Q. and Roh, J-H. (1996) Molecular Markers of Occupational Lung Cancer, Yonsei Med. J.,37, 1-18.

    Rothman, N., Hayes, R.B., Zenser, T.V., DeMarini, D.M., Bi, W., Hirvonen, A., Talaska, G., Bhatnagar, V.K., Caporaso, N., Brooks, L., Lakshmi, V., Feng, P., Kashyap, S.K., You, X., Eischen, B.T., Kashyap, R., Shelton, M.L., Hsu, F., Jaeger, M., Parikh, D.J., Davis, B., Yin, S. and Bell, D. (1996) The impact of Glutathione-S-Transferase M1 (GSTM1) null genotype on benzidine-associated bladder cancer, Urine mutagenicity and exfoliated urothelial cell DNA adducts, Cancer Epidemiol. Biomarkers and Prev., 5, 979-983.

    Warshawsky, D., Talaska, G., Schamer, M., Collins, T., Galati, A., You, L. and Stoner, G. (1996) Carcinogenicity, DNA Adduct Formation and K-ras Activation by 7H-Dibenzo(c,g)carbazole in Strain A Mouse Lung. Carcinogenesis, 17, 865-871.

    Warshawsky, D., Talaska, G., Xue, W. and Schneider, J. (1996) Comparative carcinogenicity, metabolism and DNA binding of 7H-dibenzo(c,g)carbazole and dibenz(a,j)acridine, Crit. Revs. Toxicol., 26, 213-49.

    Ward, E.M., Sabbioni, G., DeBord, D.G., Teass, A.W., Brown, K., Talaska, G., Roberts,D., Ruder, A. and Streicher, R.P. (1996) Biological monitoring of aromatic amine exposures at a chemical plant with a known bladder cancer excess, J. Natl. Cancer Instit., 88, 1046-1052.

    Vineis, P., Talaska, G., Malaveille, C., Bartsch, H., Martone, T., Sithisarankul, P., Strickland, P. (1996) DNA adducts in urothelial cells: relationship with biomarkers of exposure to arylamines and aromatic hydrocarbons from tobacco smoke, Int. J. Cancer, 65, 314-6.

    Talaska, G., Cudnick, J., Jaeger, M., Rothman, N., V.J. Bhatnagar, S.J. Kayshup, (1996) Development of non-invasive biomarkers for carcinogen-DNA adduct analysis in occupationally exposed humans: Exposure monitoring of chemical dye workers and monitoring the effectiveness of interventions to dermal exposure of used gasoline engine oils, Toxicol., 111, 207-212.

    Talaska, G., Underwood. P., Maier, A., Lewtas, J., Rothman, N. and Jaeger, M. (1996) Polycyclic Aromatic Hydrocarbons (PAH), Nitro-PAH and Related Environmental Compounds: Biological Markers of Exposure and Effects, Environ. Health Perspect., 104, 901-06.

    Schulte, P.A., Rothman, N., Perera, F.P. and Talaska, G. (1995) Biomarkers of exposure in epidemiology, Epidemiol., 6, 637-38.

    Albert, R., Miller, M., Talaska, G., Underwood, P., Cody, T. and Andringa, S. (1995) Epidermal cytokinetics, DNA adducts and dermal inflammation in the mouse in response to repeated benzo(a)pyrene exposures, Toxicol. Appl. Pharmacol., 136, 67-74.

    Schulte, P.A. and Talaska, G. (1995) Validity criteria for the use of biological markers of exposure to chemical agents in environmental epidemiology, Toxicol., 101, 73-88.

    Talaska, G., Roh, J., Schamer, M., Reilman, R., Xue, W. and Warshawsky, D. (1995) 32P-Postlabeling analysis of dibenz[a,j]acridine DNA adducts in mice: identification of pre-genotoxic metabolites, Chem. Biol. Interact., 95, 161-174.

    Vineis, P., Bartsch, H., Caporaso, N., Harrington, A.M., Kadlubar, F., Landi, M.T., Malaveille, C., Shields, P.G., Skipper, P., Talaska, G. and Tannenbaum, S.R. (1994) Genetically-based N-acetyltransferase metabolic polymorphism and low level environmental exposure to carcinogens, Nature (London), 369, 154-156.

    Talaska, G., Reilman, R., Schamer, M., Roh, J., Xue, W. Fremont, S. and Warshawsky, D. (1994) Tissue distribution of DNA adducts of 7H dibenzo(c,g)carbazole and its derivatives in mice following topical application, Chem. Res. Toxicol., 7, 374-379.

    Schulte, P.A. and Talaska, G. (1994) Molecular dosimetry in risk assessment, Cancer Bull., 46, 207-213.

    Talaska, G., Schamer, M., Casetta, G., Tizzani, A. and Vineis, P. (1994) Carcinogen-DNA adducts in bladder biopsies and urothelial cells: a risk assessment exercise, Cancer Letts. 84, 93-97.

    Warshawsky, D., Fremont, S., Xue, W., Schneider, J., Jaeger, M., Collins, T., O’Connor, P., and Talaska, G. (1994) Target organ specificity for N-heterocyclic aromatics, Polycyclic Aromatic Hydrocarbons, 6, 27-34.

    Krishnan, U., Willeke, K., Jouzaitis, A., Myojo, T., Talaska, G. and Shulka, R. (1994) Variation in quantitative respirator fit factors due to fluctuations in leak size during fit testing, Am. Ind. Hyg. Assoc. J. 55, 309-314.

    Liebhaber, F.B., Jouzaitis, A., Willeke, K., Baron, P., Talaska, G., and Chen, C-C. (1994) Technique for assessing the electrical charge of aerosols, Amer. Ind. Hyg. Assoc. J., 55, 610-618.

    Talaska, G., Schamer, M., Skipper, P., Tannenbaum, S., Caporaso, N., Unruh, L., Kadlubar, F., Bartsch, H., Malaveille, C. and Vineis, P. (1993) Carcinogen-DNA Adducts in Exfoliated Urothelial Cells: Techniques for Non-invasive Human Monitoring, Environ. Health Perspect., 99, 289-91.

    Warshawsky, D., Dietz, D., Schneider, J., Reilman, R., Xue, W., LaDow, K., Roh, J. and Talaska, G. (1993) Biotransformation of 7H-dibenzo(c,g)carbazole and dibenz(a,j)acridine in the mouse following topical application, Polycyclic Aromatic Hydrocarbons, 3, 711-717.

    Segerbäck, D., Kaderlik, K.R., Talaska, G., Dooley, K.L. and Kadlubar, F.F. (1993) 32P-postlabelling analysis of DNA adducts of 4,4′-methylenebis(2-chloraniline) in target and nontarget tissues in the dog and their implications for human risk assessment, Carcinogenesis, 14, 2143-2147.

    Kaderlik, K.R., Talaska, G., DeBord, D.G., Osorio, A.M., and Kadlubar, F.F. (1993) 4,4′-methylene-bis(2-chloraniline)-DNA adduct analysis in human exfoliated urothelial cells by 32P-postlabelling, Cancer Epidemiol. Biomarkers, Prevention, 2, 63-69.

    Roh, J-H., Schamer, M., Reilman, R., Xue, W., Warshawsky, D. and Talaska, G. (1993) 32P-Postlabeling analysis of dibenz[a,j]acridine DNA adducts in mice: preliminary determination of initial genotoxic metabolites and their effect on biomarker levels, Int. Arch. Occ. Health, 65, s99-s102.

    Talaska, G., Roh, J-H. and Getek, T. (1992) 32P-Postlabelling and mass spectrometric methods for analysis of bulky, polyaromatic carcinogen-DNA adducts in humans, J. Chromatog., 580, 293-323.

    Talaska, G., Schamer, M., Bailey, J.R., Ali, S.F., Scallet, A.C., Slikker, W. Jr. and Merle G. Paule (1992) No Increase in Carcinogen-DNA Adducts in the Lungs of Monkeys Exposed Chronically To Marijuana Smoke, Toxicol. Letts. 63, 321-332.

    Ketterer, B., Harris, J.M., Talaska, G., Meyer, D.J., Pemble, S.E., Taylor, J.B., Lang, N.P. Kadlubar, F.F. (1992) The human glutathione-S-transferase supergene family, it’s polymorphism and effects on susceptibility to lung cancer, Environ. Health Perspect., 98, 87-94.

    Flammang, T.J., Yerokun, T., Bryant, M.S., Couch, L.H., Kirlin, W.G., Lee, K.J., Ogolla, F., Ferguson, R.J., Talaska, G. and Hein, D.W. (1992) Hemoglobin adduct and hepatic and Urinary bladder DNA adduct levels in rapid and slow acetylator Syrian inbred hamsters administered 2-aminofluorene, J. Pharmacol. Exp. Therap., 260, 865-871.

    Talaska, G., Al-Juburi, A.Z.S.S. and Kadlubar, F.F. (1991) Smoking-related carcinogen-DNA adducts in biopsy samples of human urinary bladder: Identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct, Proc. Natl. Acad. Sci. (USA), 88, 5350-5354.

    Talaska, G., Schamer, M., Skipper, P., Tannenbaum, S., Caporaso, N., Unruh, L., Kadlubar, F., Bartsch, H., Malaveille, C. and Vineis, P. (1991) Detection of Carcinogen-DNA Adducts in Exfoliated Urothelial Cells of Cigarette Smokers: Correlation with Smoking, Hemoglobin Adducts, and Urinary Mutagenicity, Cancer Epidemiol. Biomarkers and Prevention, 1, 61-66.

    Bartsch, H., Caporaso, N., Coda, M., Kadlubar, F.F., Malaveille, C., Skipper, P., Talaska, G., Tannenbaum, S.R. and Vineis, P. (1991) Carcinogen-hemoglobin adducts, urine mutagenicity and metabolic phenotype in active and passive cigarette smokers, J. Natl. Cancer Inst., 82, 1826-1831.

    Casciano, D.A., Talaska, G. and Clive, D. (1991) The potent hepatocarcinogen methapyrilene induces mutations in L5178y/tk+/– mouse lymphoma cells in the apparent absence of DNA adduct formation, Mutat. Res., 263, 127-132.

    Talaska, G., Dooley, K.B. and Kadlubar, F.F. (1990) Detection and characterization of carcinogen-DNA adducts in exfoliated urothelial cells from 4-aminobiphenyl-treated dogs by [32P]postlabelling and subsequent thin layer and high pressure liquid chromatography, Carcinogenesis, 11, 639-646.

    Peluso, M., Castegnaro, M., Malaveille, C., Talaska, G., Vineis, P., Kadlubar, F., and Bartsch, H. (1990) 32P-Postlabelling analysis of DNA adducted with urinary mutagens from smokers of black tobacco, Carcinogenesis, 11, 1307-1311.

    Vineis, P., Caporaso, N., Tannenbaum. S., Skipper, P., Glogowski, J., Bartsch, H., Coda, M., Talaska, G. and Kadlubar, F.F. (1990) The acetylation phenotype, carcinogen-hemoglobin adducts and cigarette smoking, Cancer Res., 50, 3002-3004.

    Kadlubar, F.F., Talaska, G., Butler, M.A., Teitel, C.H., Massengill, J.P., and Lang, N.P. (1990) Determination of carcinogenic N-oxidation phenotype in humans by analysis of caffeine urinary metabolites, Prog. Clin. Biol. Res., 340, 107-114.

    Casciano, D.A., J.G. Shaddock, and Talaska, G. (1988) The potent hepatocarcinogen methapyrilene does not form DNA adducts in livers of Fisher 344 rats. Mutation Res., 208, 129-135.

    Talaska, G., Au, W.W., Ward, J.B. Jr., Randerath, K. and Legator, M.S. (1987) The Correlation between DNA Adducts and Chromosome Aberrations in the Target Organ of benzidine-exposed, partially-hepatectomized Mice. Carcinogenesis, 8 (12): 1895-1903.