James Lockey

Professor Emeritus

Division: OCCH

E-Mail: james.lockey@uc.edu
Phone: 513-558-0030
Location: G258 Medical Sciences Building (MSB)
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Jim Lockey

Dr. James Lockey is a Professor at the University of Cincinnati College of Medicine, Department of Environmental Health, and the Department of Internal Medicine, Pulmonary Division. Dr. Lockey’s research focus over the last thirty years has been on adverse pulmonary effects from various types of occupational and environmental exposures. Dr. Lockey’s research includes an ongoing study of the health impact from exposure to asbestiform mineral fibers found in Libby vermiculite ore; studies investigating the relationship of diesel exhaust exposure and asthma risk in a birth cohort study; a twenty-five year longitudinal study of workers exposed to refractory ceramic fibers; exposure characterization study of firefighters in collaboration with Underwriters Laboratories and cancer risk among firefighters; a study on diacetly exposure and obstructive lung disease; and the development of an environmental sensor for real-time personal exposure assessment of ultrafine particulates in collaboration with the Mechanical, Industrial and Nuclear Engineering at the University of Cincinnati. Dr. Lockey received United States Presidential appointments to the National Advisory Board on Radiation and Worker Health; and the Armed Forces Epidemiology Board and subsequently the Department of Defense, Defense Health Board. Dr. Lockey also evaluates patients with various occupational pulmonary related disorders including workers with isocyanate induced asthma and workers with a history of vermiculite exposure.

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  • 01/06/2011: Report cites cancer risks in 7 Ohio counties
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  • 09/30/2010: Dog Ownership May Help Prevent Eczema in Children with Dog Allergies
  • 10/27/2008: UC's Lockey Offers Views on Chemical Exposure in Iraq

  • Education

    1968: Kenyon College, Gambier, Ohio; BA (Biology)

    1972: Temple University, Philadelphia, PA; MD (Medicine)

    1985: University of Cincinnati, Cincinnati, OH; MS (Environmental Health)

    1972-1975: Medical Residency, Internal Medicine, University of Minnesota

    1975-1978: Pulmonary Fellowship, University of Minnesota

    1979-1980: Occupational and Environmental Fellowship, University of Cincinnati


    2000: American College of Occupational & Environmental Medicine (ACOEM)
    Presidential Award for Contribution to the Field of Occupational Medicine

    2000: City of Cincinnati Award for Service as Chair of the Environmental Advisory Council

    2010: CDC and ATSDR Nomination for the 2011 Charles C. Shepard Science Award

    2012: American College of Occupational & Environmental Medicine Adolph G. Kammer
    Merit in Authorship Award for outstanding contributions to medical literature

    Professional Experience

    1975-1977: Chief, Emergency Department, University of Minnesota Hospital

    1980-1986: Assistant Professor, Pulmonary Medicine, Occupational & Environmental Medicine, University of Utah

    1980-1986: Director of the Occupational Medicine Clinic, University of Utah

    1983-1986: Director Occupational Residency Training Program, Department of Family and Community Medicine, University of Utah School of Medicine

    1986-1990: Director, Occupational Medicine Residency Training Program, University of Cincinnati College of Medicine

    1986-1993: Associate Professor of Environmental Health, University of Cincinnati

    1986-2005: Director, Division of Occupational and Environmental Medicine, Department of Environmental Health, University of Cincinnati College of Medicine

    1988-2012: Certified “B” Reader, ILO-2000 International Classification of Radiographs for the Pneumoconiosis

    1993 – Professor of Environmental Health, University of Cincinnati

    2003- Member, Scientific Advisory Committee for Center for Asbestos Related Disease, Libby, Montana

    2003- Member, UAW-GM and UAW-Delphi Occupational Health Advisory Board

    2004 – Professor of Internal Medicine (Pulmonary), University of Cincinnati Other Experience & Professional Memberships

    2005- National Advisory Board on Radiation and Worker Health (Presidential Appointment)

    2006- Department of Defense Armed Forces Epidemiology Board (Defense Health Board)

    2008- National Research Council, Committee on Emergency and Continuous Exposure Guidance Levels for Selected Submarine Contaminants

    Selected Publications

    Lemasters GK, Lockey JE, Levin LS, McKay RT, Rice CH, Horvath EP, Papes DM, Lu JW, Feldman DJ. An industry-wide pulmonary study of men and women manufacturing refractory ceramic fiber. Am J Epidemiol, 1998;148(9):910-919.

    Welch LS, Hunting KL, Balmes J, Bresnitz EA, Guidotti TL, Lockey JE, Myo-Lwin T. Variability in the classification of radiographs using the 1980 International Labor Organization classification for pneumoconioses. Chest 1998;114:1740-1748.

    McKay RT, Levin LS, Lockey JE, Lemasters GK, Medvedovic M, Papes DM, Simpson SR, Rice CH. Weight change and lung function: Implications for workplace surveillance studies. J Occup Environ Med, 1999;41(7):596-604.

    Lentz TJ, Rice CH, Lockey JE, Succop PA, Lemasters GK. Potential significance of airborne fiber dimensions measured in U.S. refractory ceramic fiber manufacturing industry. Am J Ind Med, 1999;36:286-298.

    Lawson CC, Lemasters MK, Lemasters GK, Reutman SS, Rice CH, Lockey JE. Reliability and validity of chest radiograph surveillance programs. Chest,2001;120:64-68.

    Lockey JE, Lemasters GK, Levin L, Rice C, Yiin J, Reutman S, Papes D, et al. A longitudinal study of chest radiographic changes of workers in the refractory ceramic fiber industry. Chest, 2002;121(6):2044-2051.

    LeMasters GK, Lockey JE, Yiin JH, Hilbert TJ, Levin LS, Rice CH. Mortality of workers occupationally exposed to refractory ceramic fibers. J Occup Environ Med, 2003;45(4):440-450.

    Lentz TJ, Rice CH, Succop PA, Lockey JE, Dement JM, LeMasters GK. Pulmonary deposition modeling with airborne fiber exposure data: A study of workers manufacturing refractory ceramic fibers. J App Occ Env Hyg, 2003,18 (4):278-188.

    Rice CH, Levin LS, Borton EK, Lockey JE, Hilbert TJ, Lemasters GK. Exposures to refractory ceramic fibers in manufacturing and related operations: A 10-year update. J Occup Environ Hyg, 2005;2:462-473.

    Biagini J, LeMasters GK, Ryan P, Levin L, Reponen T, Bernstein DI, Villareal M, Hershey GK, Burkle J, Lockey J. Environmental risk factors of rhinitis in early infancy. Pediatric Allergy and Immunology. 2006 June; 17(4):278-284.

    LeMasters GK, Wilson K, Levin L, Biagini J, Ryan P, Lockey JE, et al. High prevalence of aeroallergen sensitization among infants of atopic parent. J Pediatrics. 2006, 249:505-11.

    Hu S, McDonald R, Martuzevicius D, Biswas P, Grinshpun SA, Kelley A, Reponen T, Lockey J, LeMasters G. UNMIX modeling of ambient PM2.5 near an interstate highway in Cincinnati, Ohio USA. Atmospheric Environment. 2006, 49(S2):378-395.

    LeMasters GK, Genaidy AM, Succop P, Deddens J, Sobeih T, Barriera-Viruet H, Dunning K, Lockey J. Cancer risk among firefighters: A review and meta-analysis of 32 studies. J Occup Environ Med. 48:1189-1202, 2006.

    Campo P, Kalra H, Levin L, Reponen T, Olds R, Lummus Z, Cho S-H, Hershey G, Lockey J, Villareal M,Stanforth S, LeMasters G, Bernstein D. Influence of dog ownership and high endotoxin on wheezing and atopy during infancy. J Allergy and Clin Immunol. 118(6):1271-1278, 2006.

    Vesper J, McKinstry C, Haugland R, Iossifova Y. LeMasters G, Levin L, Hershey GK, Villareal M, Bernstein DI, Lockey J, Reponen T. EPA relative moldiness index as predictor of childhood respiratory illness. J Exposure Science and Environmental Epidemiology. 17:88-94, 2007.

    Ryan PH, LeMasters GK, Biswas, P, Levin L, Hu S, Lindsey M, Bernstein DI, Lockey J, Villareal M, Hershey GKK, Grinshpun SA. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environ Health Perspect. 115 :278-284, 2007.

    Iossifova Y, Reponen T, Bernstein D, Levin L, Kalra H Campo P, Villareal M, Lockey J, Hershey G, LeMasters G. House dust (1-3)-ß-D glucan and wheezing in infants. Allergy. 62:504-513, 2007.

    Genaidy AM, LeMasters GK, Lockey JE, Succop P, Dedens J, Sobeih T, Dunning K. An epidemiological appraisal instrument – A tool for evaluation of epidemiological studies. Ergonomics. 50(6);920-960, 2007.

    Rohs, AM, Lockey, JE, Dunning KK, Shukla R, Fan H, Hilbert T, Borton E, Wiot J, Meyer Cristopher, Shipley RT, Lemasters GK, Kapil V. Low level fiber induced radiographic changes caused by Libby vermiculite: A 25-year follow up study. Am J Respir Crit Care Med, 177:630-637, 2008.

    Smith AM, Bernstein DI, LeMasters GK, Huey NL, Ericksen M, Villareal M, Lockey J, Hershey GKK. Environmental Tobacco Smoke and Interleukin 4 Polymorphism (C-589T) Gene: Environment Interaction Increases Risk of Wheezing in African-American Infants. J Pediatrics,152(5):709-15, May, 2008.

    Schroer KT, Biagini JM, Ryan PH, LeMasters GK, Bernstein DI, Villareal M, Lockey JE, Reponen T, Grinshpun S, Hershey GKK. Associations between multiple environmental exposures and glutathione S-transferase P1 on persistent wheezing in a birth cohort. (in press, J Pediatrics)

    Franzblau A, Kazerooni EA, Sen A, Goodsitt MM, Lee S-Y, Rosenman KD, Lockey JE, Meyer CA, Gillespie BWQ, Petsonk EL, Wang ML. Comparison of digital radiographs with film-screen radiographs for classification of pneumoconiosis. (in press, Academic Radiology)

    Iossifova YY, Reponen T, Ryan PH, Levin L, Bernstein DI, Lockey JE, Hershey GKK, Villareal M, LeMasters G. Mold exposure during infancy as a strong predictor of potential asthma development. (in press, Annals of Allergy, Asthma and Immunology)

    Lockey JE, Utell M, Hilbert T, Levin, L, Ryan P, White K, Borton E, Rice C, McKay RT, LeMasters GK. Airway obstruction related to diacetyl exposure at microwave popcorn production facilities. (in press, European Respiratory Journal)

    Lockey JE. Man-made fibers and nonasbestos fibrous silicates. In: Occupational and Environmental Respiratory Disease, Harber P, Schenker M, Balmes J, eds. St. Louis: Mosby, 330-344, 1996.

    Lockey JE, Ross CS. Health effects of man-made fibres. In: ILO Encyclopaedia of Occupational Health and Safety, 4th ed, Stellman JM (Editor-in-Chief). Geneva, Switzerland: ILO/WHO, 1998; 10.74-10.78.

    Lockey JE. Physiological Fate of Asbestos and Vitreous Fibers Less Than 5 Microns in Length. Health Effects of Asbestos and Vitreous Fibers Less Than 5 Microns in Length. Data Gaps. In: Report on the Expert Panel on Health Effects of Asbestos and Synthetic Vitreous Fibers: The Influence of Fiber Length. Prepared for: ATSDR by Eastern Research Group, Inc. March 2003;23-34.

    Lockey JE, Kapil V, Weise N. Man-made vitreous fibers, vermiculite, and zeolite. In: Environmental and Occupational Medicine, 4th edition. ed. William N. Rom. Lippincott-Raven Publishers, Philadelphia. 2007.

    Rohs, AM, Lockey, JE, Dunning KK, Shukla R, Fan H, Hilbert T, Borton E, Wiot J, Meyer Cristopher, Shipley RT, Lemasters GK, Kapil V. Low level fiber induced radiographic changes caused by Libby vermiculite: A 25-year follow up study. Am J Respir Crit Care Med 2008; 177:630-637.

    Lockey JE, Hilbert T, Levin, L, Ryan P, White K, Borton E, Rice C, McKay RT, LeMasters GK. Airway obstruction related to diacetyl exposure at microwave popcorn production facilities. Eur Respir J 2009; 34: 63-71.

    White K, Heikkila K, Williams R, Levin L, Lockey J, Rice C. Diacetyl exposures at four microwave popcorn plants. J Occup Environ Hyg 2010; 7(4): 185-93.

    McKay RT, LeMasters GK, Hilbert TJ, Levin LS, Rice CH, Borton EK, Lockey JE. A long term study of pulmonary function among U.S. refractory ceramic fibre workers. Occup Environ Med 2011; 68:89-95.

    Ryan PH, Dihle M, Griffin S, Partridge C, Taylor R, Hilbert T, Adjei S, Lockey JE. Erionite in road gravel associated with interstitial and pleural changes – An occupational hazard in Western United States. J Occup Environ Med 2011; 53(8): 893-899.

    Lockey JE, Roggli VL, Hilbert TJ, Rice CH, Levin LS, Borton EK, Biddinger PW, LeMasters GK. Biopersistence of refractory ceramic fiber in human lung tissue and a 20-year follow-up of radiographic pleural changes in workers. J Occup Environ Med 2012; 54(7): 781-788.

    Dunning KK, Adjei S, Levin L, Rohs AM, Hilbert T, Borton E, Kapil V, Rice C, LeMasters GK, Lockey JE. Mesothelioma associated with commercial use of vermiculite containing Libby amphibole. JOEM, 2012; 54(11): 1359-1363.

    Borton EK, LeMasters GK, Hilbert TJ, Lockey JE, Dunning KK, Rice CH. Exposure estimates for workers in a facility expanding Libby vermiculite: Updated values and comparison to original 1980 values. JOEM; 2012; 54(11):1350-1358.