Mary Beth Genter

Associate Professor

Division: Toxicology

E-Mail: marybeth.genter@uc.edu
Phone: 513-558-6266
Location: 144 Kettering Lab
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Mary Beth Genter

My laboratory focuses on the olfactory system, both with regard to toxic responses of the olfactory mucosa and to the plasticity of olfactory neurons. Techniques include genomics, immunohistochemistry, enzymatic activity and knock out models. We are also interested in more general aspects of neurotoxicology and neurodegenerative diseases, including drug-induced memory loss and therapeutic interventions in neurological diseases.

Related News:

  • 02/29/2012: Are plastics a health problem?
  • 08/31/2011: Avoiding Pesticides
  • 08/25/2011: Preventing Pesticide Exposure In and Outside the Home

  • Education

    1988-1990 Postdoctoral studies at the Chemical Industry Institute of Toxicology (now the Hamner Institute), RTP, NC

    1984-1988 Ph.D., Integrated Toxicology Program Department of Pathology, Duke University, Durham, NC

    1980-1984 B.S. Magna cum laude Chemistry, Biology St. Lawrence University Canton, NY

    Awards

    Society of Toxicology Mechanisms Specialty Section Student Award (1988)

    Society of Toxicology Neurotoxicology Specialty Section Student Award (1986, 1988)

    North Carolina Society of Toxicology Travel Awards (1986, 1988)

    NIEHS Toxicology Traineeship, Duke University Integrated Toxicology Program (1984-1987)

    American Institute of Chemists Student Research Award (1984) Phi Beta Kappa (1984)

    Who’s Who Among Students in American Colleges and Universities (1983)

    Selected for “Fast Breaking Research Presentation “Mechanism of Toxicology” Gordon Conference, July 2002.

    Professional Experience

    2008 – present Editor-in-Chief, International Journal of Toxicology.

    2004 – 2008 Served on Board of the American Board of Toxicology

    1999 -Present Associate Professor Department of Environmental Health University of Cincinnati Cincinnati, OH

    1995 – 1998 Department of Molecular and Cellular Physiology University of Cincinnati Cincinnati, OH

    May-Oct. 1995 Associate Professor, with tenure Department of Toxicology North Carolina State University Raleigh, NC

    June 1990-1995 Assistant Professor Department of Toxicology North Carolina State University Raleigh, NC

    1988-1990 Postdoctoral Fellow Chemical Industry Institute of Toxicology Research Triangle Park, NC

    Grants

    5-R03-CA-102944-02-A0-S0-E007/01/2003-06/30/2006. National Cancer Institute. Extracellular Matrix in Chloracetanilide Carcenogenesis, PI, Closed.

    1-R21-DC-006505-01-A0-S0-E009/26/2003-08/31/2006. National Institute on Deafness and Other Communication Disor. Sphingolipid signaling in olfactory mucosa, PI, Closed.

    1-R25-RR-16301-01-A1-S0-E009/30/2002-08/31/2005. National Center for Research Resources. HealthRICH: Health Risks Information and Choices Phase I, PI, Closed.

    5-R01-AG-13837-03-A0-S0-E009/15/1995-08/31/1999. National Institute on Aging. Impact of Environmental Toxicants on the Olfactory System, PI, Closed.

    5-R01-ES-08799-05-A0-S0-E004/01/1999-03/31/2005. National Institute of Environmental Health Sciences. Mechanisms of Induction of Olfactory Tumors by Alachlor, PI, Closed.

    470423 / R25 RR0160107/01/2007-04/30/2009. National Center for Research Resources. Phase II HealthRICH: Health Risks, PI, Closed.

    IRUSQUET046707/15/2008-11/14/2010. AstraZeneca, PLC. (United Kingdom). Beyond Dopamine and Serotonin: Regulation of Neurotophins, Neurogenesis, and Neuroplasticity by Quietiapine/Norquetiapine as a Marker of Antidepressa, Collaborator, Closed.

    SRS 00585109/15/2008-09/14/2011. National Alliance for Research on Schizophrenia and Depression. Acetaminophen vs. Metformin and Rosiglitazone: Can an OTC Replace Prescription Drugs in the Reversal of Antipsychotic Drug-Induced Metabolic Complicat, PI, Closed.

    5 U45 ES06162-1708/01/2008-07/31/2009. National Institute of Environmental Health Sciences. ICWUC Worker Health and Safety Training Cooperative, Collaborator, Closed.

    U45 ES06116208/01/2009-07/31/2010. National Institute of Environmental Health Sciences. Worker Health and Safety Training Cooperative Agreement HWWT, Collaborator, Closed.

    Sarquis-ARRA-NCRR-G70530 / R25 RR01630109/09/2009-09/08/2010. National Center for Research Resources. HealthRICH: Health Risks, Information, and Choices, Phase II, PI, Closed.

    U45 ES06162-1908/01/2010-07/31/2012. National Institute of Environmental Health Sciences. Hazardous Material Worker Health and Safety Training, Collaborator, Closed.

    T42 OH00843207/01/2011-06/30/2016. National Institute for Occupational Safety and Health. Education and Research Center, Collaborator, Active.

    HWWT / U45 ES06162-2008/01/2011-07/31/2012. National Institute of Environmental Health Sciences. Worker Health and Safety Training Cooperative Agreement HWWT, Collaborator, Closed.

    Hershberger-NIH-UC/ R23RR03220807/01/2011-03/31/2016. National Center for Research Resources. Fighting with Food: Battling Chemical Toxicity with Good Nutrition, PI, Active.

    Study ILO522DUSNC05T07/15/2012-04/30/2014. Novartis AG. Effects of Iloperidone on Neuron Mitochondrial Function, Collaborator, Closed.

    U45 ES0616208/01/2012-07/31/2013. National Institute of Environmental Health Sciences. Worker Health and Safety Training Cooperative Agreement ICWUC(HWWT), Collaborator, Closed.

    HWWT U45ES0612-2208/01/2013-07/31/2014. National Institute of Environmental Health Sciences. Worker Health and Safety Training Cooperative Agreement-HWWT, Collaborator, Closed.

    Sub to 5U45ES0978-2309/01/2014-08/31/2015. National Institute of Environmental Health Sciences. Worker Health and Safety Training for DOE Nuclear Weapons Workers, Collaborator, Active.

    SUB 5U45ES06162-2308/01/2014-07/31/2015. National Institute of Environmental Health Sciences. Hazardous Materials Worker Health and Safety Training Cooperative (U45) HWWT ES06162, Collaborator, Active.

    Selected Publications

    Genter, Mary Beth (2014). Editor’s Note.. International Journal of Toxicology, 33 (4), 267. doi:10.1177/1091581814545735

    Hsieh, H., Amlal, H., & Genter, M. (2014). Evaluation of the toxicity of zinc in the rat olfactory neuronal cell line, Odora.. Human & Experimental Toxicology. doi:10.1177/0960327114538985

    Shertzer, H. G., Krishan, M., & Genter, M. B. (2013). Dietary whey protein stimulates mitochondrial activity and decreases oxidative stress in mouse female brain.. Neuroscience Letters, 548, 159-64. doi:10.1016/j.neulet.2013.05.061

    Dong, H., Shertzer, H. G., Genter, M. B., Gonzalez, F. J., Vasiliou, V., Jefcoate, C., & Nebert, D. W. (2013). Mitochondrial targeting of mouse NQO1 and CYP1B1 proteins.. Biochemical and Biophysical Research Communications, 435 (4), 727-32. doi:10.1016/j.bbrc.2013.05.051

    Sasso, A. F., Schlosser, P. M., Kedderis, G. L., Genter, M. B., Snawder, J. E., Li, Z., Rieth, S., & Lipscomb, J. C. (2013). Application of an updated physiologically based pharmacokinetic model for chloroform to evaluate CYP2E1-mediated renal toxicity in rats and mice.. Toxicological Sciences : An Official Journal of the Society of Toxicology, 131 (2), 360-74. doi:10.1093/toxsci/kfs320

    Barchowsky, A., Buckley, L. A., Carlson, G. P., Fitsanakis, V. A., Ford, S. M., Genter, M. B., Germolec, D. R., Leavens, T. L., Lehman-McKeeman, L. D., Safe, S. H., Sulentic, C. E. W., & Eidemiller, B. J. (2012). The Toxicology Education Summit: building the future of toxicology through education.. Toxicological Sciences : An Official Journal of the Society of Toxicology, 127 (2), 331-8. doi:10.1093/toxsci/kfs111

    Genter, Mary Beth (2011). Editor’s Note.. International Journal of Toxicology, 30 (4), 383. doi:10.1177/1091581810394984

    Shertzer, H. G., Woods, S. E., Krishan, M., Genter, M. B., & Pearson, K. J. (2011). Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet.. The Journal of Nutrition, 141 (4), 582-7. doi:10.3945/jn.110.133736

    Curran, C. P., Vorhees, C. V., Williams, M. T., Genter, M. B., Miller, M. L., & Nebert, D. W. (2011). In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.. Toxicological Sciences : An Official Journal of the Society of Toxicology, 119 (1), 189-208. doi:10.1093/toxsci/kfq314

    Genter, M. B., Krishan, M., Augustine, L. M., & Cherrington, N. J. (2010). Drug transporter expression and localization in rat nasal respiratory and olfactory mucosa and olfactory bulb.. Drug Metabolism and Disposition: the Biological Fate of Chemicals, 38 (10), 1644-7. doi:10.1124/dmd.110.034611

    Hopf, N. B., Kirkeleit, J., Kramer, S. L., Moen, B., Succop, P., Genter, M. B., Carreón, T., Mack, J., & Talaska, G. (2010). Urinary 1-hydroxypyrene levels in offshore workers.. International Archives of Occupational and Environmental Health, 83 (1), 55-9. doi:10.1007/s00420-009-0437-2

    Genter, M. B., Kendig, E. L., & Knutson, M. D. (2009). Uptake of materials from the nasal cavity into the blood and brain: are we finally beginning to understand these processes at the molecular level?. Annals of the New York Academy of Sciences, 1170, 623-8. doi:10.1111/j.1749-6632.2009.03877.x

    Genter, M. B., Warner, B. M., Medvedovic, M., & Sartor, M. A. (2009). Comparison of rat olfactory mucosal responses to carcinogenic and non-carcinogenic chloracetanilides.. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association, 47 (6), 1051-7. doi:10.1016/j.fct.2009.01.030

    Shertzer, H. G., Schneider, S. N., Kendig, E. L., Clegg, D. J., D’Alessio, D. A., Johansson, E., & Genter, M. B. (2009). Tetrahydroindenoindole inhibits the progression of diabetes in mice.. Chemico-biological Interactions, 177 (1), 71-80. doi:10.1016/j.cbi.2008.09.001

    Kendig, E. L., Schneider, S. N., Clegg, D. J., Genter, M. B., & Shertzer, H. G. (2008). Over-the-counter analgesics normalize blood glucose and body composition in mice fed a high fat diet.. Biochemical Pharmacology, 76 (2), 216-24. doi:10.1016/j.bcp.2008.05.001

    Shertzer, H. G., Genter, M. B., Talaska, G., Curran, C. P., Nebert, D. W., & Dalton, T. P. (2007). 7H-dibenzo[c,g]carbazole metabolism by the mouse and human CYP1 family of enzymes.. Carcinogenesis, 28 (6), 1371-8. doi:10.1093/carcin/bgl244

    Shertzer, H. G., Genter, M. B., Shen, D., Nebert, D. W., Chen, Y., & Dalton, T. P. (2006). TCDD decreases ATP levels and increases reactive oxygen production through changes in mitochondrial F(0)F(1)-ATP synthase and ubiquinone.. Toxicology and Applied Pharmacology, 217 (3), 363-74. doi:10.1016/j.taap.2006.09.014

    Genter, M. B., Marlowe, J., Kevin Kerzee, J., Dragin, N., Puga, A., Dalton, T. P., & Nebert, D. W. (2006). Naphthalene toxicity in mice and aryl hydrocarbon receptor-mediated CYPs.. Biochemical and Biophysical Research Communications, 348 (1), 120-3. doi:10.1016/j.bbrc.2006.07.025

    Genter, M. B., Clay, C. D., Dalton, T. P., Dong, H., Nebert, D. W., & Shertzer, H. G. (2006). Comparison of mouse hepatic mitochondrial versus microsomal cytochromes P450 following TCDD treatment.. Biochemical and Biophysical Research Communications, 342 (4), 1375-81. doi:10.1016/j.bbrc.2006.02.121

    Genter, M. B., Warner, B. M., Krell, H., & Bolon, B. (2005). Reduction of alachlor-induced olfactory mucosal neoplasms by the matrix metalloproteinase inhibitor Ro 28-2653.. Toxicologic Pathology, 33 (5), 593-9.

    Zhang, J., Moseley, A., Jegga, A. G., Gupta, A., Witte, D. P., Sartor, M., Medvedovic, M., Williams, S. S., Ley-Ebert, C., Coolen, L. M., Egnaczyk, G., Genter, M. B., Lehman, M., Lingrel, J., Maggio, J., Parysek, L., Walsh, R., Xu, M., & Aronow, B. J. (2004). Neural system-enriched gene expression: relationship to biological pathways and neurological diseases.. Physiological Genomics, 18 (2), 167-83. doi:10.1152/physiolgenomics.00220.2003

    Ling, G., Gu, J., Genter, M. B., Zhuo, X., & Ding, X. (2004). Regulation of cytochrome P450 gene expression in the olfactory mucosa.. Chemico-biological Interactions, 147 (3), 247-58. doi:10.1016/j.cbi.2004.02.003

    Shertzer, H. G., Clay, C. D., Genter, M. B., Chames, M. C., Schneider, S. N., Oakley, G. G., Nebert, D. W., & Dalton, T. P. (2004). Uncoupling-mediated generation of reactive oxygen by halogenated aromatic hydrocarbons in mouse liver microsomes.. Free Radical Biology & Medicine, 36 (5), 618-31. doi:10.1016/j.freeradbiomed.2003.11.014

    Genter, Mary Beth (2004). Update on olfactory mucosal metabolic enzymes: age-related changes and N-acetyltransferase activities.. Journal of Biochemical and Molecular Toxicology, 18 (4), 239-44. doi:10.1002/jbt.20029

    Genter, M. B., Burman, D. M., Vijayakumar, S., Ebert, C. L., & Aronow, B. J. (2002). Genomic analysis of alachlor-induced oncogenesis in rat olfactory mucosa.. Physiological Genomics, 12 (1), 35-45. doi:10.1152/physiolgenomics.00120.2002

    Senft, A. P., Dalton, T. P., Nebert, D. W., Genter, M. B., Puga, A., Hutchinson, R. J., Kerzee, J. K., Uno, S., & Shertzer, H. G. (2002). Mitochondrial reactive oxygen production is dependent on the aromatic hydrocarbon receptor.. Free Radical Biology & Medicine, 33 (9), 1268-78.

    Genter, M. B., Apparaju, S., & Desai, P. B. (2002). Induction of olfactory mucosal and liver metabolism of lidocaine by 2,3,7,8-tetrachlorodibenzo-p-dioxin.. Journal of Biochemical and Molecular Toxicology, 16 (3), 128-34. doi:10.1002/jbt.10032

    Uno, S., Dalton, T. P., Shertzer, H. G., Genter, M. B., Warshawsky, D., Talaska, G., & Nebert, D. W. (2001). Benzo[a]pyrene-induced toxicity: paradoxical protection in Cyp1a1(-/-) knockout mice having increased hepatic BaP-DNA adduct levels.. Biochemical and Biophysical Research Communications, 289 (5), 1049-56. doi:10.1006/bbrc.2001.6110

    Dalton, T. P., Dieter, M. Z., Matlib, R. S., Childs, N. L., Shertzer, H. G., Genter, M. B., & Nebert, D. W. (2000). Targeted knockout of Cyp1a1 gene does not alter hepatic constitutive expression of other genes in the mouse [Ah] battery.. Biochemical and Biophysical Research Communications, 267 (1), 184-9. doi:10.1006/bbrc.1999.1913

    Wetmore, B. A., Mitchell, A. D., Meyer, S. A., & Genter, M. B. (1999). Evidence for site-specific bioactivation of alachlor in the olfactory mucosa of the Long-Evans rat.. Toxicological Sciences : An Official Journal of the Society of Toxicology, 49 (2), 202-12.

    Genter, M. B., Liang, H. C., Gu, J., Ding, X., Negishi, M., McKinnon, R. A., & Nebert, D. W. (1998). Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse.. Biochemical Pharmacology, 55 (11), 1819-26.

    Gu, J., Zhang, Q. Y., Genter, M. B., Lipinskas, T. W., Negishi, M., Nebert, D. W., & Ding, X. (1998). Purification and characterization of heterologously expressed mouse CYP2A5 and CYP2G1: role in metabolic activation of acetaminophen and 2,6-dichlorobenzonitrile in mouse olfactory mucosal microsomes.. The Journal of Pharmacology and Experimental Therapeutics, 285 (3), 1287-95.

    Millhorn, D. E., Conforti, L., Beitner-Johnson, D., Zhu, W., Raymond, R., Filisko, T., Kobayashi, S., Peng, M., & Genter, M. B. (1996). Regulation of ionic conductances and gene expression by hypoxia in an oxygen sensitive cell line.. Advances in Experimental Medicine and Biology, 410, 135-42.

    Genter, M. B., Owens, D. M., & Deamer, N. J. (1995). Distribution of microsomal epoxide hydrolase and glutathione S-transferase in the rat olfactory mucosa: relevance to distribution of lesions caused by systemically-administered olfactory toxicants.. Chemical Senses, 20 (4), 385-92.

    Deamer, N. J., O’Callaghan, J. P., & Genter, M. B. (1994). Olfactory toxicity resulting from dermal application of 2,6-dichlorobenzonitrile (dichlobenil) in the C57Bl mouse.. Neurotoxicology, 15 (2), 287-93.

    Genter, M. B., & Recio, L. (1994). Absence of detectable P450 2E1 in bone marrow of B6C3F1 mice: relevance to butadiene-induced bone marrow toxicity.. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology, 22 (3), 469-73.

    Genter, M. B., Deamer, N. J., Cao, Y., & Levi, P. E. (1994). Effects of P450 inhibition and induction on the olfactory toxicity of beta,beta’-iminodipropionitrile (IDPN) in the rat.. Journal of Biochemical Toxicology, 9 (1), 31-9.

    Rosenberg, C. K., Genter, M. B., Szakál-Quin, G., Anthony, D. C., & Graham, D. G. (1987). dl- versus meso-3,4-dimethyl-2,5-hexanedione: a morphometric study of the proximo-distal distribution of axonal swellings in the anterior root of the rat.. Toxicology and Applied Pharmacology, 87 (2), 363-73.

    Genter, M. B., Szakál-Quin, G., Anderson, C. W., Anthony, D. C., & Graham, D. G. (1987). Evidence that pyrrole formation is a pathogenetic step in gamma-diketone neuropathy.. Toxicology and Applied Pharmacology, 87 (2), 351-62.

    Genter, Mary BethI am amazed at how time flies, and that we are now reading the fifth issue of International Journal of Toxicology for 2009!. International Journal of Toxicology, 28 (5), 339-40. doi:10.1177/1091581809345248

    Genter, M. B., Goss, K. H., & Groden, J. Strain-specific of alachlor on murine olfactory mucosal responses.. Toxicologic Pathology, 32 (6), 719-25.

    Deshpande, V. S., Genter, M. B., Jung, C., & Desai, P. B. Characterization of lidocaine metabolism by rat nasal microsomes: implications for nasal drug delivery.. European Journal of Drug Metabolism and Pharmacokinetics, 24 (2), 177-82.

    Crofton, K. M., Zhao, X., Sayre, L. M., & Genter, M. B. Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats.. Neurotoxicology and Teratology, 18 (3), 297-303.

    Genter, M. B., Deamer, N. J., Blake, B. L., Wesley, D. S., & Levi, P. E. Olfactory toxicity of methimazole: dose-response and structure-activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa.. Toxicologic Pathology, 23 (4), 477-86.