Shuk-Mei Ho

Jacob G. Schmidlapp Professor and Chair
Department of Environmental Health
Hayden Family Endowed Chair
Director, Cincinnati Cancer Center

E-Mail: Shuk-mei.ho@uc.edu
Phone: 513-558-5701 ext. 1
Location: 130 Kettering Lab
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Shuk-Mei Ho

Shuk-Mei Ho, PhD is internationally recognized for her expertise in the role of hormones and endocrine disruptors on disease development including tumorigenesis in the prostate, ovary, endometrium and breast. The 2015 recipient of the University of Cincinnati’s Rieveschl Award for Distinguished Scientific Research, she has made major contributions to our understanding of the impact of heavy metals, oxidative stress and inflammation on carcinogenesis; the discovery of biomarkers for cancer detection and patient classification, and mechanism-based drug development. Dr. Ho’s research employs state-of-the-art investigative tools for genomics, transcriptomics, proteomics, epigenomics, and informatics research focused on improving predictive, preventive medicine.

Dr. Ho’s work explores the developmental origins of disease susceptibility by applying epigenetics to epidemiological studies, thereby addressing two important challenges of research in environmental exposure and human health: multiple exposures at various developmental stages and the trans-generational effects of exposure. Her recent findings on exposure to endocrine disrupting compounds (EDC), including Bisphenol A, have helped to better inform the clinical and public health communities about in utero exposure to EDC in food and drinking water. She also has obtained preliminary data implicating epigenetic dysregulation of transcriptional regulation as the bases of polycyclic aromatic hydrocarbon (PAH)-associated disorders such as asthma and cancer.

Dr. Ho is an active participant in the Endocrine Society, the Society of Toxicology, the American Association for Cancer Research, Prostate Cancer Research Program, the American Urologic Society and the Society for Basic Urologic Research (SBUR). She is past president of the latter. Today she regularly chairs scientific review and policy committees for the National Institutes of Health and the Department of Defense. She is a member of the Integration Panel of the Department of Defense Congressionally Directed Prostate Cancer Research Program, and serves on the Emerging Science Committee of the National Academy of Science. Dr. Ho has been honored by the Ohio Senate (127th General Assembly) and has received the Women in Urology Award from the SBUR and the Society of Women in Urology. In August 2014, she was profiled in the journal of Endocrine Related Cancer as a nationally and internationally recognized leader in the field.

Dr. Ho has published more than 200 papers in prestigious, peer-reviewed journals. She is Jacob G. Schmidlapp Professor and Chair of the University of Cincinnati Department of Environmental Health and Director of the Cincinnati Cancer Center. She also serves as the Director of the NIEHS funded Center for Environmental Genetics and Director of the Genomics Epigenomics and Sequencing Core.

Related News:

  • 04/01/2014: New study links BPA and prostate cancer in humans
  • 03/04/2014: Study links chemical exposure to prostate cancer
  • 03/03/2014: BPA Linked to Prostate Cancer Study Shows
  • 02/01/2014: Community engagement drives new pilot study on fracking and air quality
  • 01/02/2014: 2013 TOP RESEARCH AWARD
  • 11/05/2013: Breast Cancer Research
  • 10/24/2013: Cancer rates climbing in Butler County
  • 09/04/2013: Environmental Health Faculty Students Enjoy Successful Conference in Basel Switzerland
  • 08/29/2013: Researchers Identify Key Protein's Role in Cancer Development
  • 07/01/2013: NIEHS spurs investigation into the health effects of e-waste recycling
  • 06/21/2013: Center for Environmental Genetics Announces Career Development Awards
  • 06/17/2013: $8.7 Million Grant Supports 'Gene-Environment Interaction' Research
  • 02/01/2013: Dr. Ho's group uses saliva for study on methylation in asthma
  • 08/08/2011: Cancer Biomarker?Detectable by Blood Test?Could Improve Prostate Cancer Detection
  • 01/04/2011: Epigenetics and Disease Outcome
  • 01/11/2010: UC wins $5M stimulus grant for lab renovations
  • 09/18/2009: Estrogen May Explain the Higher PCa Risk in Blacks
  • 04/01/2009: Study Links Maternal Exhaust Exposure to Childhood Asthma
  • 02/15/2009: Pollution Link to Asthma in Womb
  • 02/15/2009: Prenatal Exposure to Traffic Pollution May Lead to Asthma
  • 02/01/2009: Study Offers Insight into Endocrine Disruption by Soy
  • 01/16/2009: Genetic Data May Predict Colon Cancer Odds
  • 01/16/2009: Cancer ?Hot Spots? Found
  • 11/23/2008: Environmental Health Chair Leads Organizing Committee for Meeting
  • 05/19/2008: Another Bastion of Research
  • 05/19/2008: UC Med School Hauls in Funding
  • 04/01/2008: 7.8 Million Grant Supports Gene-Environment Interaction Research
  • 02/26/2008: Distinguished Lecture Series on Advances in Toxicology and Risk Assessment
  • 12/01/2007: Environment Health Chair Selected to Assist With Study
  • 07/22/2007: UC Environmental Health Chair Recognized Nationally for Urologic Research Excellence
  • 03/12/2007: Plastic Dangers
  • 07/01/2006: Chemical in Plastics is Tied to Prostate Cancer
  • 01/01/2006: Series on Experimental Oncology and its Clinical Application

  • Education

    University of Hong Kong B.Sc. 1974 Biological Sciences

    University of Hong Kong Ph.D. 1978 Zoology

    Professional Experience

    1977-1980 Research Associate, Department of Biology, Boston University

    1980-1981 Visiting Assistant Professor, Department of Biology, Boston University

    1981-1986 Assistant Professor, Department of Biology, Tufts University

    1986-1995 Associate Professor, Department of Biology, Tufts University

    1995-1999 Professor, Department of Biology, Tufts University

    1997-1999 Associate Dean for Research, School of Graduate Studies,Research and Continued Education, Tufts University

    1999-2005 Professor of Surgery and Cell Biology, University of Massachusetts Medical School

    1999-2005 Director of Urological Research and Translational Research for the Department of Surgery, University of Massachusetts Medical School

    2000-2005 Member Diabetes & Endocrinology Research Center Program (DERC), Univ. Mass. Med. Sch.

    2001-2005 Professor of Physiology, University of Massachusetts Medical School

    2005 Vice Chair of Research, Department of Surgery, University of Massachusetts Medical School

    2005-present Professor and Chair, Department of Environmental Health, University of Cincinnati Medical School

    2006-present Director, Center for Environmental Genetics, University of Cincinnati

    2008-present National Academy of Science, Member Committee on Use of Emerging Science for Environmental Health Decisions

    Grants

    R01 CA11253207/01/2006-05/31/2012. National Cancer Institute. Hormone-Induced Inflammation and Prostate Cancer, PI, Closed.

    R01 CA11257009/30/2005-05/31/2011. National Cancer Institute. Progesterone-mediated protection against ovarian cancer, PI, Active.

    R21 ES01307109/30/2005-06/30/2008. National Institute of Environmental Health Sciences. Developmental Modulation of Mouse Uterine Tumorigenesis, PI, Closed.

    R01 CA1577609/30/2005-05/31/2010. National Cancer Institute. Prostatic Differentiation and Sex Hormone Metabolism, PI, Closed.

    R01 CA06226905/26/2006-08/31/2009. National Cancer Institute. Metallothionein and Cadmium Carcinogenesis in the Prostate, PI, Closed.

    P30 ES0609604/01/2002-03/31/2008. National Institute of Environmental Health Sciences. Environmental Genetics, PI, Closed.

    09/30/2005-06/30/2007. National Cancer Institute. CYP1A1, Estrogen Metabolism and Ovarian Carcinogenesis, PI, Closed.

    R21 ES01228103/01/2006-02/28/2007. National Institute of Environmental Health Sciences. Estrogen Imprinting of the Prostate Gland Via Methylation, PI, Closed.

    W81XWH-04-01-016503/15/2006-02/04/2008. Department of the Army Medical Research and Materiel Command. Estrogen Receptor-Beta Hypermethylation and Prostate Carcinogenesis, PI, Closed.

    P50 ES015905 / 5-7574109/29/2007-05/31/2013. National Institute of Environmental Health Sciences. The Role of Airborne PAHs and DEP in the Pathogenesis of Childhood Asthma, PI, Active.

    SRS 00544101/01/2008-06/30/2009. Ausio Pharmaceuticals LLC. Ausio Pharmaceuticals-Contract, PI, Closed.

    2007-04409 / R01-ES01558401/15/2008-11/30/2012. National Institute of Environmental Health Sciences. Epigenetic Basis for Prostate Carcinogenesis Following Early Estrogenic Exposures, PI, Closed.

    P30 ES006096-16A104/01/2008-03/31/2013. National Institute of Environmental Health Sciences. Environmental Genetics, PI, Active.

    W81XWH-08-1-044309/02/2008-09/01/2012. Department of the Army Medical Research Acquisition Activity. Regulation of PCNA Function by Tyrosine Phosphorylation in Prostate Cancer, Collaborator, Active.

    K99 ES01681709/02/2008-08/31/2010. National Institute of Environmental Health Sciences. Estrogens/Xenoestrogens and Epigenetic Regulation of Gene Expression, Collaborator, Closed.

    R13 DK08320409/15/2008-08/31/2009. National Inst of Diabetes and Digestive and Kidney Disease. The 18th Annual Meeting of the SBUR: Epigenetics and Genitourinary Disorders, PI, Closed.

    R01 CA12537909/01/2008-07/31/2014. National Cancer Institute. The Ron Receptor/Chemokine Axis in Prostate Cancer, Collaborator, Active.

    31-310005045309/01/2006-06/30/2008. National Institute of Environmental Health Sciences. Chris Curran and Eric Kendig-CHMC Training Grant, PI, Closed.

    EB00373007/01/2009-01/15/2012. National Institute of Biomedical Imaging and Bioengineering. Assembly of Phi29 pRNA Nanoparticles for siRNA Delivery to Prostate Cancer Cells, Collaborator, Closed.

    R01 EY01522706/01/2009-05/31/2014. National Eye Institute. The Role of MAP 3 Kinase 1 in Ocular Surface Morphogenesis, Collaborator, Active.

    F31 EY01945803/01/2010-02/28/2011. National Eye Institute. Molecular Regulation of MAP3 Kinase1 in Ocular Morphogenesis, Collaborator, Closed.

    CU / 3 P50 ES015905-03S109/01/2009-08/31/2011. National Institute of Environmental Health Sciences. The Role of Airborne PAHS and DEP in the Pathogenesis of Childhood Asthma, PI, Closed.

    28751 / 98013852 / RC2 ES01878909/24/2009-08/31/2011. National Institute of Environmental Health Sciences. Developmental Reprogramming of Prostate Carcinogenesis by BPA, PI, Closed.

    E4753 / RC2ES01875809/21/2009-06/30/2011. National Institute of Environmental Health Sciences. Developmental Exposure to Low-Dose Bisphenol A and Human Prostate Cancer, PI, Closed.

    E4779 / R01ES015584-02S109/04/2009-08/31/2011. National Institute of Environmental Health Sciences. Epigenetic Basis for Prostate Carcinogenesis following Early Estrogenic Exposures, PI, Closed.

    W81XWH-09-1-001201/15/2009-02/14/2012. Department of the Army Medical Research Acquisition Activity. Exposure to Maternal Diabetes in Utero and Transgenerational Breast Cancer Risk, Collaborator, Closed.

    1 C06 RR028634-01 Rev01/07/2010-12/31/2014. National Center for Research Resources. Kettering Lab Renovation to Enhance PHS-Supported Environmental Health Research, PI, Active.

    K07 CA13871409/08/2010-08/31/2015. National Cancer Institute. Global and Specific Oxidation Pathways Related to Prostate Cancer, Prospective and Cross-Sectional Analyses, Collaborator, Active.

    U01 ES01948009/22/2010-05/31/2015. National Institute of Environmental Health Sciences. Susceptible Window of High Fat Diet/Bisphenol A Programming of Breast Cancer Risk, PI, Active.

    RC4 ES01975509/27/2010-09/30/2013. National Institute of Environmental Health Sciences. Human Developmental Toxicity of Metal Mixture Exposure from E-Waste Recycling, Collaborator, Active.

    W81XWH-11-1-032304/01/2011-07/20/2012. Department of the Army Medical Research Acquisition Activity. Investigation of S-Nitrosylation of Integrin Alpha 6 in Prostate Cancer Metastasis, PI, Closed.

    VA IPA Ouyang04/01/2011-03/31/2014. Department of Veterans Affairs. Intergovernmental Personnel Act Agreement for Bin Ouyang, Collaborator, Active.

    R21 CA15604208/01/2011-07/31/2014. National Cancer Institute. Gene Methylation Targets for Prostate Cancer Prevention by Early Soy Exposure, Collaborator, Active.

    U01ES02098809/19/2011-05/31/2015. National Institute of Environmental Health Sciences. Chronic Exposure to Bisphenol A and Uterine Cancer Risk Markers, PI, Active.

    2011-04282-01-00 / U01ES02088606/01/2012-05/31/2015. National Institute of Environmental Health Sciences. Prostatic Effects of Chronic Exposure to Bisphenol A in Rat Model, PI, Active.

    R21EB01212204/01/2012-03/31/2014. National Institute of Biomedical Imaging and Bioengineering. Smart, Enzyme-Activated MRI Contrast Agents for Cancer Detection, Collaborator, Active.

    S10OD01194404/02/2012-03/31/2014. Office of the Director, National Institutes of Health. Bruker Avance III Wide-Bore (89-mm, 9.4T), Vertical-Bore 400-Mhz NMR Spectrometer, Collaborator, Active.

    PO 415923-G ES00124707/25/2012-09/30/2013. National Institute of Environmental Health Sciences. Health and Hydrofracking: Comparative Assessment of Community Information Needs, PI, Active.

    2012-02586-01-00 R01ES02207108/23/2012-04/30/2017. National Institute of Environmental Health Sciences. Effects of Arsenic on Human Prostate Stem Cells and Prostate Cancer Risk, PI, Active.

    11212355057091/ R01ES02147702/01/2013-10/31/2013. National Institute of Environmental Health Sciences. Glucose Metabolism in Adults Prenatally Exposed to Diabetogenic Pollutants, PI, Active.

    P30ES00609604/01/2013-03/31/2018. National Institute of Environmental Health Sciences. Environmental Genetics, PI, Active.

    Selected Publications

    Selected Publications from the last 10 years from 178 publications.

    Brunst KJ, Leung YK, Ryan PH, Khurana Hershey GK, Levin L, Ji H, Lemasters GK, Ho SM. (2012) Forkhead box protein 3 (FOXP3) hypermethylation is associated with diesel exhaust exposure and risk for childhood asthma. J Allergy Clin Immunol. 12:18 pii: S0091-6749(12)01763-0. doi: 10.1016/j.jaci.2012.10.042. PMID: 23260754.

    Jin C, Chen J, Meng Q, Carreira V, Tam NN, Geh E, Karyala S, Ho SM, Zhou X, Medvedovic M, Xia Y. (2012) Deciphering Gene Expression Program of MAP3K1 in Mouse Eyelid Morphogenesis. Dev Biol. doi:pii: S0012-1606(12)00639-2. 10.1016/j.ydbio.2012.11.020. PMID: 23201579

    Isaac J, Tarapore P, Zhang X, Lam YW, Ho SM. (2012) Site-specific S-nitrosylation of Integrin α6 Increases Prostate Cancer Cell Migration by Increasing Integrin β1 Association and Reducing Adherence to Laminin-1. Biochemistry , Nov 16. PMID: 23106339

    Ouyang B, Baxter CS, Lam HM, Yeramaneni S, Levin L, Haynes E, Ho SM. (2012) Hypomethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene. J Occup Environ Med. 7;54(7):774-80. PMID: 22796920

    Walker CL and Ho SM. (2012) Developmental reprogramming of cancer susceptibility. Nature Reviews Cancer, 6.14. doi: 10.1038/nrc3220. PMID: 22695395.

    Privette Vinnedge LM, Ho SM, Wikenheiser-Brokamp KA, Wells S (2012) The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS ONE 7(10):e46985. doi: 10.1371/journal.pone.0046985. PMID: 23071688

    Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK (2012) Environmental epigenetics: A multidimensional interactome point of view. Institute of Laboratory Animal Res Journal (in press).

    Ouyang B, Baxter CS, Lam H-M, Yeramaneni S, Levin L, Haynes EN, Ho SM (2012) Demethylation of dual specificity phosphatase 22 promoter correlates with duration of service in firefighters and is inducible by low-dose benzo[a]pyrene. J of Occupational & Environmental Medicine 54:774-780. PMID: 22796920.

    Tang WY, Talaska G, Cheung YY, Levin L, Herbstman J, Miller RL, Perera F, Ho SM. (2012) Maternal exposure to polycyclic aromatic hydrocarbons is associated with methylation at a 5’-CpG island of interferon-gamma in cord white blood cells. Environmental Health Perspectives Aug;120(8):1195-200. doi: 10.1289/ehp.1103744. PMID: 22562770.

    Leung YK, Lee MT, Lam HM, Tarapore P, Ho SM. (2012) Estrogen receptor β research in breast cancer: Translating biology into clinical practice. Steroids Jun;77(7):727-37. doi: 10.1016/j.steroids.2012.03.008. PMID: 22465878, The most downloaded article from SciVerse ScienceDirect July to September 2012.

    Greathouse KL, Bredfeldt T, Everitt JI, Lin K, Berry T, Kannan K, Mittelstadt ML, Ho SM, and Walker CL. (2012) Environmental estrogens differentially engage the histone methyltransferase EZH2 to increase risk of uterine tumorigenesis. Molecular Cancer Research 10:546-557 PMID: 22504913

    Lam HM, Babu S, Wang J, Yuan Y, Lam YW, Ho SM*, Leung Y-K* (2012) Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion, Molecular Cellular Endocrinology. 358:27-35. PMID: 22370157 (co-corresponding authors)

    Tang WY, Morey LM, Cheung YY, Birch L, Prins GS and Ho SM (2012) Neonatal estradiol/bisphenol A exposure alters promoter methylation status of Nsbp1 and Hpcal1 and transcriptional programs of Dnmt 3b and Mbd2 in rat prostate during adulthood. Endocrinology 153:42-55, PMID: 22109888

    Howard TD, Ho SM, Zhang L, Chen J, Cui W, Slager R, Gray S, Hawkins GA, Medvedovic M, Wagner JD (2011) Epigenetic changes with dietary soy in Cynomolgus monkeys. PLoS ONE 6(10):e26791. PMID: 22046358

    Ho SM, Lee MT, Lam HM, Leung YK. (2011) Estrogens and prostate cancer: etiology, mediators, prevention, and management. Endocrinol Metab Clin North Am. 40:591-614. PMID: 21889723.

    Chatterjee TK, Idelman G, Blanco V, Blomkalns AL, Piegore M, Weintraub DS, Kumar S, Rajsheker S, Manka D, Rudich S, Tang Y, Hui DY, Bassel-Duby R, Olson EN, Lingrel JB, Ho SM, and Weintraub NL. (2011) Histone deacetylase 9 is a negative regulator of adipogenic differentiation. J Biological Chemistry, 286:27836-27847, PMID: 21680747, PMCID: PMC3149373.

    Wu T, Giovannucci E, Welge J, Mallick P, Tang WY, Ho SM. (2011) Measurement of GSTP1 promoter methylation in body fluids may complement PSA screening: a meta-analysis. Br J Cancer. 105:65-73. PMID: 21654682

    Leung YK, Ho SM. (2011) Estrogen Receptor β: Switching to a new partner and escaping from estrogen. Science Signaling, 4(168):pe19. PMID: 21487104

    Hu WY, Shi G-B, Lam H-M, Hu D-P, Ho SM, Madueke IC, Kajdacsy-Balla A, and Prins GS. (2011) Estrogen-initiated transformation of prostate epithelium derived from normal human prostate stem-progenitor cells. Endocrinology, 152:2150-2163. PMID: 21427218

    Zhang X and Ho SM. (2011) Epigenetics meets endocrinology. J Mol Endocrinol. 46:R11-32. PMID: 21106863

    Zhou Q, Ching AK, Leung WK, Szeto CY, Ho SM, Chan PK, Yuan YF, Lai PB, Yeo W, Wong N. (2011) Novel therapeutic potential in targeting microtubules by nanoparticle albumin-bound paclitaxel in hepatocellular carcinoma. Int J Oncol. 38:721-731. PMID: 21240457

    Ouyang B, Leung YK, Wang V, Chung E, Levin L, Bracken B, Cheng L, and Ho SM. (2011) Alpha-methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology 77:249.e1-7. PMID: 21195844

    Chen A, Dietrich KN, Huo X, Ho SM. (2011) Developmental neurotoxicants in E-waste: An emerging health concern. Environmental Health Perspectives 119:431-438. PMID: 21081302

    Tarapore P, Shu Y, Guo P, and Ho SM. (2011) Application of Phi29 motor pRNA for targeted therapeutic delivery of siRNA silencing metallothionein-IIA and survivin in ovarian cancers. Molecular Therapy 19:386-394, PMID: 21063391

    Prins GS, Ye SH, Birch L, Ho SM, Kannan K. (2011) Serum bisphenol A pharmacokinetics and prostate neoplastic responses following oral and subcutaneous exposures in neonatal Sprague-Dawley rats. Reprod Toxicol. 31:1-9, PMID: 20887781

    Tam NN, Szeto CY, Freudenberg JM, Fullenkamp AN, Medvedovic M, Ho SM. (2010) Research Resource: Estrogen-Driven Prolactin-Mediated Gene-Expression Networks in Hormone-Induced Prostatic Intraepithelial Neoplasia. Mol Endocrinol 24:2207-2217, PMID: 20861223

    Ho SM. (2010) Environmental epigenetics of asthma: an update. J Allergy Clin Immun. 126:453-465. PMID: 20816181

    Panchanathan R, Shen H, Zhang X, Ho SM, and Choubey D. (2010) Mutually positive regulatory feedback loop between interferons and estrogen receptor-alpha in mice: implications for sex bias in autoimmunity, PLoS ONE, 5:e10868. PMID: 20526365

    Leung YK, Lam HM, Wu S, Song D, Levin L, Cheng L, Wu CL and Ho SM. (2010) Estrogen receptor beta2 and beta5 are associated with poor prognosis in prostate cancer and promote cancer cell migration and invasion. Endocr Relat Cancer. 17:675-689. PMID: 20501637

    Lam YW, Yuan Y, Isaac J, Suresh Babu CV, Meller J and Ho SM. (2010) Comprehensive identification and modified-site mapping of S-nitrosylated targets in prostate epithelial cells, PLoS ONE. 5: e9075. PMID: 20140087

    Joseph D, Ho SM, and Syed V. (2010) Hormonal regulation and distinct functions of semaphorin-3B and semaphorin-3F in ovarian cancer. Molecular Cancer Therapeutics. 9:499-509. PMID: 20124444

    Zhang X, Wu M, Xiao H, Lee MT, Levin L, Leung YK, and Ho SM. (2010) Methylation of a single intronic CpG mediates expression silencing of the PMP24 gene in prostate cancer. Prostate 70:765-776. PMID: 20054818

    Chan QKY, Lam H-M, Ng CF, Lee AYY, Chan ESY, Ng H-K, Ho SM*, and Lau K-M* (2010) Activation of GPR30 inhibits prostate cancer cell growth via sustained Erk1/2 activation, p21(WAF1/CIP1) upregulation, and induction of G2 cell cycle arrest. (*co-corresponding author). Cell Death and Differentiation 17:1511-1523 PMID: 20203690

    Zhao H, Ou-Yang F, Chen I-F, Hou M-F, Yuan S-S F, Chang H-L, Lee Y-C, Plattner R, Waltz S, Ho SM, Sims J, and Wang S-C. (2010) Enhanced resistance to tamoxifen by the c-ABL proto-oncogene in breast cancer. Neoplasia 12:214-223. PMID: 20234815

    Estes MD, Ouyang B, Ho SM, and Ahn CH. (2009) Isolation of prostate cancer cell subpopulations of functional interest by use of an on-chip magnetic bead-based cell separator. J. Micromech. Microeng. 19:129901. (http://iopscience.iop.org/0960-1317/19/12/129901)

    Curran CP, Park RM, Ho SM, and Haynes EN. (2009) Incorporating Genetics and Genomics in Risk Assessment for Inhaled Manganese: From Data to Policy. Neurotoxicology, 30: 754-760. PMID: 19646473

    Perera F, Tang WY, Herbstman JB, Tang DT, Levin L, Miller RL and Ho SM. (2009) Relation of DNA methylaton status of a 5’-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma. PLoS ONE . 4:e4488. PMID: 19221603

    Zhang X, Leav I, Revelo MP, Deka R, Medvedovic M, Jiang Z, and Ho SM. (2009) Deletion hotspots in AMACR promoter CpG island are cis-regulatory elements controlling the gene expression in the colon. PLoS Genetics 5:e1000334. PMID: 19148275

    Ouyang B, Bracken B, Burke B, Chung E, Liang J, and Ho SM. (2009) A duplex qRCR assay based on quantification of α-methylacyl-CoA racemase transcripts and prostate cancer antigen 3 in urine sediments improved diagnostic accuracy for prostate cancer. J Urol . 181:2508-2513. PMID: 19371911

    Xiong SD, Liu XH, Yin HF, Kirschenbaum A, Yao S, Narla G, DiFeo A, Yu K, Wu JB, Yuan Y, Ho SM , Lam Y-W, and Levine AC. (2009) Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells. Int. J. Cancer 125:774-782. PMID: 19384952

    Schiewer MJ, Morey LM, Burd CJ, Liu Y, Merry DE, Ho SM, and Knudsen, KE (2009) Cyclin D1 repressor domain mediates proliferation and survival in prostate cancer. Oncogene 19:28:1016-1027. PMID: 19079343

    Myers JP, vom Saal FS, Akingbemi BT, Ho SM, Belcher S, et.al. (2008) Why public health agencies cannot depend upon ‘Good Laboratory Practices’ as a criterion for selecting data: The case of bisphenol A. Environ. Health Perspect 117:309-315. PMID: 19337501

    Crain DA, Janssen SJ, Edwards TM, Heindel J, Ho SM, Hunt P, Iguchi T, Juul A, McLachlan JA, Schwartz J, Skakkebaek N, Soto AM, Swan S, Walker C, Woodruff TK, Woodruff TJ, Giudice LC, and Guillette LJ Jr. (2008) Female reproductive disorders: the roles of endocrine-disrupting compounds and developmental timing. Fertil Steril. 90:911-940. PMID: 18929049

    Tang WY, Newbold R, Mardilovich K, Jefferson W, Cheng RYS, Medvedovic M, and Ho SM. (2008) Persistent hypomethylation in the promoter of nucleosomal binding protein 1 (Nsbp1) correlates with overexpression of Nsbp1 in mouse uteri neonatally exposed to diethylstilbestrol or genistein. Endocrinology 149(12):5922-31. PMID: 18669593

    Bakshi S, Zhang X, Godoy-Tundidor S, Cheng RYS, Sartor MA, Medvedovic M, and Ho SM. (2008) Transcriptome analyses in normal prostate epithelial cells exposed to low-dose cadmium: Oncogenic and immunomodulations involving the action of tumor necrosis factor. Environ. Health Perspect 116:769-776. PMID: 18560533

    Lam YW, Tam NNC, Evans J, Green K, Zhang X, and Ho SM. (2008) Differential proteomics in the aging Noble rat ventral prostate. Proteomics 8:2750-2763. PMID: 18546156

    Prins GS, Tang WY, Belmonte J, and Ho SM. (2008) Developmental exposure to bisphenol A increases prostate cancer susceptibility in adult rats: epigenetic mode of action is implicated. Fertil Steril. 89:e41. PMID: 18308059

    Tam NNC, Szeto CY, Sartor M, Medvedovic M, and Ho SM. (2008) Gene expression profiling identifies lobe-specific and common disruptions of multiple gene networks in testosterone-supported, 17-estradiol- or diethylstilbestrol-induced prostate dysplasia in Noble rats. Neoplasia 10:20-40. PMID: 18231636

    Prins GS, Tang WY, Belmonte J, and Ho SM. (2008) Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis. Basic Clin Pharmacol Toxicol. 102:134-138. PMID: 18226066

    Miller RL and Ho SM. (2008) Environmental epigenetics and asthma: Current concepts and call for studies. Am. J. Respir. Crit. Care Med., 177:567-573. PMID: 18187692

    Miller RL & Ho SM (2008) Epigenetic studies should focus on specific cell types. Am J Resp Crit Care Me 178, 883.

    Choubey D, Deka R, and Ho SM. (2008) Interferon-inducible IFI16 Protein in human cancers and autoimmune diseases. Frontiers in Bioscience 13:598-608. PMID: 17981573

    Tam NNC and Ho SM. (2008) Culture of whole embryonic kidneys: present status and beyond. J. Urol. 179:17. PMID: 17997421

    Alimirah F, Panchanathan R, Chen J, Zhang X, Ho SM and Choubey D. (2007) Expression of androgen receptor is negatively regulated by p53. Neoplasia, 9:1152-1159. PMID: 18084622

    Hess-Wilson JK, Webb SL, Daly HE, Leung YK, Boldison J, Comstock CES, Sartor MA, Ho SM, Knudsen KE. (2007) Unique bisphenol A transcriptome in prostate cancer: novel effects on ERß expression that correspond to AR mutation status. Environ. Health Perspect. 115:1646-1653. PMID: 18007998

    Vom Saal FS, Akingbemi BT, Belcher SM, Birnbaum LS, Crain DA, Eriksen M, Farabollini F, Guillette LJ Jr, Hauser R, Heindel JJ, Ho SM, Hunt PA, Iguchi T, Jobling S, Kanno J, Keri RA, Knudsen KE, Laufer H, Leblanc GA, Marcus M, McLachlan JA, Myers JP, Nadal A, Newbold RR, Olea N, Prins GS, Richter CA, Rubin BS, Sonnenschein C, Soto AM, Talsness CE, Vandenbergh JG, Vandenberg LN, Walser-Kuntz DR, Watson CS, Welshons WV, Wetherill Y, Zoeller RT. (2007) Chapel Hill bisphenol A expert panel consensus statement: Integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol. 24:131-138. PMID: 17768031

    Tam NNC, Leav I, and Ho SM. (2007) Sex hormones induce direct epithelial and inflammation-mediated oxidative/nitrosative stress that favors prostatic carcinogenesis in the Noble rat. Am. J. Pathol. 171: 1334-1341. PMID: 17717140

    Keri RA, Ho SM, Hunt PA, Knudsen KE, Soto AM, Prins GS. (2007) An evaluation of evidence for the carcinogenic activity of bisphenol A. Reprod. Toxicol. 24:240-252. PMID: 17706921

    Prins GS, Birch L, Tang WY, Ho SM. (2007) Developmental estrogen exposures predispose to prostate carcinogenesis with aging. Reprod. Toxicol. 23: 374-382. PMID: 17123779

    Tang WY and Ho SM. (2007) Epigenetic reprogramming and imprinting in origins of disease. Rev. Endocr. Metab. Disord. 8:173-182. PMID: 17638084

    Zhang X, Leung YK and Ho SM. (2007) AP-2 regulates the transcription of estrogen receptor (ER)-β by acting through a methylation hotspot of the 0N promoter in prostate cancer cells. Oncogene 26:7346-7354. PMID: 17525739

    Syed V, Mukherjee K, Godoy-Tundidor S, and Ho SM. (2007) Progesterone induces apoptosis in TRAIL-resistant ovarian cancer cells by circumventing c-FLIPL overexpression. J. of Cell. Biol. 102:442-452. PMID: 17393432

    Ho SM and Tang WY. (2007) Techniques used in studies of epigenome dysregulation due to aberrant DNA methylation:an emphasis on fetal-based adult diseases. Reprod Toxicol.23:267-282. PMID: 17317097

    Mak P, Leung YK, Tang WY, Harwood C, Ho SM. (2006) Apigenin suppresses cancer cell growth through ERβ. Neoplasia 8:896-904. PMID: 17132221

    Leung YK, Mak P, Hassan S, Ho, SM. (2006) Estrogen receptor (ER) B isoforms: A key to understanding ER-β isoforms: A key to understanding ER-β signaling. Proc. Natl. Acad. Sci. U S A. 103:13162-13167.Erratum in: Proc. Natl. Acad. Sci. U S A. 103:14977. PMID: 16938840

    Ho SM, Tang WY, Belmonte de Frausto J, and Prins GS. (2006) Developmental exposure to estradiol and bisphenol A Increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res. 66:5624-5632. PMID: 16740699

    Ho SM, Leung YK and Chung I. (2006) Estrogens and Antiestrogens as Etiological Factors and Therapeutics for Prostate Cancer. Ann. N.Y. Acad. Sci. 1089:177–193. PMID: 17261766

    Leung YK, Gao Y, Lau KM, Zhang X, Ho SM. (2006) ICI 182, 780-regulated gene expression in DU145 prostate cancer cells is mediated by estrogen receptor-beta/NFkappaB crosstalk. Neoplasia 8:242-249. PMID: 16756716

    Sun CQA, Arnold R, Fernandez-Golarz C, Parish AB, Almekinder T, He J, Ho SM, Svoboda P, Pohl J, Marshall FF, Petros JA (2006) Human B-defensin-1, a potential chromosome 8p tumor suppressor: Control of transcription and induction of apoptosis in renal cell carcinoma. Cancer Research, 66:8542-8549. PMID: 16951166

    Languino LR, Ho SM. (2006) Andorgen action series. Viewpoint. J Cell Biochem: 99:331-332. PMID: 17632872

    Tam N, Nyska A, Maronpot R, Kissling G, Lomnitski L, Suttie A, Bakshi S, Bergman M, Grossman, S, Ho SM. (2006) Differential attenuation of oxidative/nitrosative injuries in early prostatic neoplastic lesions in TRAMP mice by dietary antioxidants. Prostate 66:57-69. PMID: 16114064

    Syed V, Zhang X, Lau K-M, Mukherjee K, Ho SM. (2005) Transcriptional profiling of estrogen regulated genes expression changes in immortalized normal and malignant human ovarian surface epithelial cells. Oncogene 24:8128-8143. PMID: 16116479

    Kim K, Sun P, Troncoso P, Sabichi AL, Babaian RJ, Pisters LL, Pettaway CA, Wood CG, Lam Y-W Lippman SM, McDonnell TJ, Lieberman R, Mobley JA, Logothetis C, and Ho SM. (2005) Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer. Cancer Epidemiol. Biomarker Prevention. 14:1697-1702. PMID: 16030104

    Lam YW, Mobley JA, Evans JE, and Ho SM. (2005) Profiling and multidimensional separation of serum proteins: Identification of Platelet Factor 4 (CXC chemokine ligand 4) which lost expression in metastatic prostate cancer. Proteomics 5:2927-2938. PMID: 15952230

    Leung YK, Lau, KM, Mobley JA, Jiang Z, and Ho SM. (2005) Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells; alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res 65:3726-3734. PMID: 15867368

    Mukherjee K, Syed V, and Ho SM. (2005) Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells. Oncogene 24:4388-4400. PMID: 15806153

    Syed S, Mukherjee K, Lyons-Weiler J, Lau K-M, Mashima T, Tsuruo T, and Ho SM. (2005) Identification ATF-3, Caveolin-1, DLC-1 and NM23-H2 as putataive antitumorigenic protesterone-regulated genes for ovarian cancer cells by gene profiling. Oncogene 24:1774-1787. PMID: 15674352

    Ho SM. (2005) Metal ions as endocrine disruptors: implications for prostate cancer. In: Endocrine Disruptors: Effects on Male and Female Reproductive System. Edited by Rajash K. Naz, p.p. 411-430, CRC Press. Boca Raton, London, New York, Washington D.C.

    Bostwick DG, Burke HB, Djakiew D, Euling S, Ho SM, Landolph J, Morrison H, Sonawane B, Shifflett T, Waters DJ, and Timms B. (2004) Human Prostate Cancer Risk Factors. Cancer (Supplement) 101:2371-2490. PMID: 15495199

    Lai JS, Brown LG, True LD, Hawley SJ, Etzioni R, Higano CS, Ho SM, and Vessella RL. (2004) Metastases of prostate cancer express estrogen receptor-beta. Urology 64:814-820. PMID: 15491740

    Ho SM and Cheng RYS. (2004) A promising bladder cancer detection assay the HA-HAase test. J. Urol. 172:824-825. PMID: 15310975

    Zielie PJ, Mobley JA, Ebb RG, Jiang Z, Blute RD, and Ho SM. (2004) A novel diagnostic test for prostate cancer emerges from the determination of α-methylacyl-CoA racemase in prostatic secretions. J. Urol. 172:1130-1133. PMID: 15311056

    Zhu X, Leav I, Leung YK, Wu M-C, Liu Q, Gao Y, McNeal JE and Ho SM. (2004) Dynamic regulation of estrogen receptor-b expression by DNA methylation during prostate cancer development and metastasis. Am. J. Pathol 164: 2003-2012. [Accompanied Commentary: Domann FE, Futscher BW Flipping the epigenetic switch. Am J Pathol. 164:1883-1886. PMID: 15161636

    Mobley JA, L’Esperance JO, Wu M-C Friel CJ, Hanson RH and Ho SM. (2004) A novel estrogen 17- 20Z-21-[(4-amino)phenyl]-19-norpregna-1,3,5(10),20-tetraene-3,17-diol induces apoptosis in prostate cancer cell lines at nanomolar concentrations in vitro. Mol. Cancer Ther, 3:587-595. PMID: 15141016

    Mobley JA, Lam Y-W, Lau KM, Pais VM, L’Esperance JO, Steadman B, Burgos Fuster LM, Blute RD, Taplin ME, and Ho SM. (2004) Monitoring the serologic proteome; The latest modality in prostate cancer detection. J. Urol. 172:331-337. PMID: 15201806

    Ho SM. (2004) Estrogens and anti-estrogens: Key mediators of prostate carcinogenesis and new therapeutic candidates. J. Cell. Biochem. 91:491-503. PMID: 14755680

    Wu M-C, and Ho SM. (2004) PMP24, a gene identified by MSRF, undergoes DNA hypermethylation-associated gene silencing during cancer progression in a LNCaP model. Oncogene 23:250-259. PMID: 14712230

    Tam NNC, Gao Y, Leung YK, and Ho SM. (2003) Androgenic regulation of oxidative stress in the rat prostate: involvement of NAD(P)H oxidases and antioxidant defense machinery during prostatic involution and regrowth. Am. J. Pathol. 163:2513-2522. PMID: 14633623

    Syed V, and Ho SM. (2003) Progesterone-induced apoptosis in immortalized normal and malignant human ovarian surface epithelial cells involves enhanced expression of FasL. Oncogene 22:6883-6890. PMID: 14534535

    Pais V, Leav I, Lau K-M, Jiang Z and Ho SM. (2003) Estrogen receptor-β expression in human testicular germ cell tumors. Clin. Cancer Research 9: 4475-4482. PMID: 14555521

    Ho, SM. (2003) Estrogen, progesterone and epithelial ovarian cancer. J Reprod. Biol. Endocrinol. 1:73-78. PMID: 14577831

    Mobley JA, Leav I, Zielie P, Wotkowitz C, Evans J, Lam Y-W, L’Esperance B, Jiang Z, and Ho SM. (2003) Branched fatty acids in dairy and beef products markedly enhance -methylacyl-CoA racemase expression in prostate cancer cells in vitro. Cancer Epidemiol. Biomarker Prevention. 12:775-783. PMID: 12917210

    Lau K-M, Tam NNC, Thompson C, Cheng R, Leung YK, and Ho SM. (2003) Identification of differentially expressed genes in the ventral prostates of young and old rats using t-statistics analysis on cDNA microarray data. Lab. Invest. 83:743-757.

    Ho SM, Lau KM, Mok SC and Syed V. (2003) Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells. Oncogene 22:4243-4256. PMID: 12833147

    Kwong J, Lui K, Chan PSF, Ho SM, Wong YC, Xuan JW, and Chan FL. (2003) An expression study of three secretory proteins (prostate secretary protein of 94 amino acids, probasin and seminal vesicle secretion II) in dysplastic and neoplastic rat prostates. Prostate 56:81-97 PMID: 12746832

    Leav I, McNeal JE, Ho SM, Jiang Z. (2003) -methylacyl-CoA racemase (P504S) expression in evolving carcinomas with benign prostatic hyperplasia and in cancer of the transition zone. Human Pathol. 34:228-233. PMID: 12673556

    Tam NNC, Ghatak S, and Ho SM. (2003) Sex Hormone-induced alterations in the activities of antioxidant enzymes and lipid peroxidation status in the prostate of Noble rats. Prostate 55:1-8. PMID: 12640655

    Syed V, Ulinski G, Mok SC, and Ho SM. (2002) Reproductive hormone-induced, STAT3-mediated IL-6 action in normal and malignant human ovarian surface epithelial cell. J. Nat’l Cancer Inst. 94:617-629. PMID: 11959895

    Murphy LC, Leygue E, Niu Y, Snell L, Ho SM, Watson P. (2002) Relationship of co-regular and estrogen receptor isoform expression to de novo tamoxifen resistance in human breast cancer. Brit. J. Cancer 87:1411-1416.

    Melnick R, Lucier G, Wolfe M, Hall R, Stancel G, Prins G, Gallo M, Reuhl K, Ho, SM, Brown T, Moore J, Leakey J, Haseman J, Kohn M. (2002) Summary of the National Toxicology Program’s Report of the Endocrine Disruptors Low-Dose Peer Review. Environ. Health. Perspect. 110:427-431. PMID: 11940462

    Thompson CJ, Tam NNC, Joyce JM, Leav I, and Ho SM. (2002) Gene expression profiling of changes associated with combined testosterone and estradiol-17-induced lateral prostate dysplasia in the Noble rats and their response to the pure antiestrogen ICI 182,780. Endocrinology. 143:2093-2105. PMID: 12021174

    Adams JY, Leav I, Lau K-M, Ho SM, and Pflueger SMV. (2002) Expression of estrogen receptor beta in the fetal, neonatal and prepubertal human prostate. Prostate 52:69-81. PMID: 11992621

    Ho SM and Lau K-M. (2002) DNA Microarrays in Prostate Cancer Current Urology Reports, 3:53-60. PMID: 12084220

    Tekur S, and Ho SM. (2002) Ribozyme mediated down-regulation of human metallothionein IIa induces apoptosis in human prostate and ovarian cancer cell lines. Molecular Carcinogenesis 33:44-55. PMID: 11807957